First-pass dynamic contrast-enhanced MRI with extravasating contrast reagent: evidence for human myocardial capillary recruitment in adenosine-induced hyperemia.

NMR in Biomedicine
Xin LiMichael Jerosch-Herold

Abstract

Human myocardial (1)H(2)O T(1)-weighted dynamic contrast-enhanced MRI data were acquired during the brief first-pass period after injection of a very small gadolinium diethylenetriaminepenta-acetate (GdDTPA(2-)) dose. The shutter-speed pharmacokinetic effects of both transendothelial and transcytolemmal equilibrium water exchange processes were investigated. Our results indicate that even for such a short acquisition window and relatively large pseudo-first-order rate constant (K(trans)) for plasma/interstitium contrast reagent (CR) transfer the kinetics of these water exchange processes cannot be treated as infinitely fast or slow. However, neither the intracellular water molecule lifetime (tau(i)) nor its intravascular counterpart (tau(b)) are among the parameters most influential in analysis of the noisy data typically associated with the cardiac perfusion application. Thus, the actual values of water exchange kinetic rate constants are relatively indeterminate as this experiment is usually conducted. Combining the K(trans) evaluations with independently determined flow (F) values allows us to estimate CR permeability coefficient surface area product (P(CR)S) values. The fact that the P(CR)S magnitudes almost equal the K(tra...Continue Reading

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