PMID: 7018538Jun 1, 1981Paper

First-pass lung uptake of propranolol enhanced in anaesthetized dogs

British Journal of Anaesthesia
J A PangD M Geddes

Abstract

Uptake of 14C-propranolol after a single passage through the pulmonary circulation was studied in three groups of Labrador dogs using a double indicator dilution method. Uptake in conscious, ambulant animals was 53%. This increased to 81% in dogs anaesthetized with thiopentone, nitrous oxide and halothane and to 64% in dogs anaesthetized with thiopentone, nitrous oxide and fentanyl. Interaction between lipid-soluble anaesthetic agents and pulmonary endothelial cell membranes may be an important factor in increasing lung uptake of lipophilic propranolol, although alteration in pulmonary perfusion associated with a reduction in cardiac output during general anaesthesia may play a part. The pharmacological effects of propranolol administered i.v. during general anaesthesia may be unpredictable.

Citations

Jan 1, 1986·Lung·J A PangD M Geddes
Jan 1, 1981·Lung·J A Pang, D M Geddes
Jul 1, 1999·Clinical and Experimental Pharmacology & Physiology·R N Upton, D J Doolette
Dec 1, 1990·Biopharmaceutics & Drug Disposition·R N UptonL E Mather

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