First report of colistin resistance among carbapenem-resistant Acinetobacter baumannii isolates recovered from hospitalized patients in Egypt

New Microbes and New Infections
Amani T AbdulzahraWalid F Elkhatib

Abstract

Acinetobacter baumannii is an opportunistic pathogen that poses an increasing threat in the health-care community. Colistin is one of the promising options for treatment of multidrug-resistant A. baumannii. The current study investigated the emergence of colistin resistance among carbapenem-resistant strains of A. baumannii in Egypt. It involved identification of clinically recovered A. baumannii isolates using the VITEK-2 system, and screening of their antimicrobial susceptibilities using broth microdilution techniques. Characterizations of carbapenemase and 16S rRNA methyltransferase genes were performed using PCR. Colistin-resistance determinants were characterized by sequencing. Carbapenem-resistant A. baumannii isolates (n = 40) showed resistance to amoxicillin-clavulanic acid, cefotaxime, gentamicin and amikacin. Most isolates revealed resistance to ciprofloxacin (95%; n = 38) and co-trimoxazole (92.5%; n = 37). Resistance to tobramycin and doxycycline was 80% (n = 32) and 62.5% (n = 25), respectively. Only two A. baumannii isolates demonstrated colistin resistance. Carbapenemase activity was tested by modified Hodge test and 78% of isolates were positive. All isolates carried blaOXA-51-like genes whereas bla-OXA-23 was d...Continue Reading

Citations

Dec 14, 2019·Current Microbiology·Aisha M AlAmriAmani M AlNimr
Jun 21, 2020·Antimicrobial Resistance and Infection Control·Olaniyi AyobamiRobby Markwart
Nov 12, 2020·Revista Da Sociedade Brasileira De Medicina Tropical·Mariana Neri Lucas KuriharaSimone Simionatto
Jun 4, 2021·Infection and Drug Resistance·Amani El-KholyRamy Kotb
Jun 8, 2021·New Microbes and New Infections·P RashvandN Habibollah-Pourzereshki

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Datasets Mentioned

BETA
LC371058
LC371059

Methods Mentioned

BETA
PCR
PCRs

Software Mentioned

EXPASY
ClustalW2
BLAST

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