First report of Creutzfeldt-Jakob disease occurring in 2 siblings unexplained by PRNP mutation.

Journal of Neuropathology and Experimental Neurology
Thomas E F WebbJohn Collinge

Abstract

Sibling concurrence of pathologically confirmed prion disease has only been reported in association with pathogenic mutation of the prion protein gene (PRNP). Here, we report 2 siblings with classic neuropathologic features of sporadic Creutzfeldt-Jakob disease unexplained by PRNP mutation or known risk factors for iatrogenic transmission of prion infection. Possible explanations include coincidental occurrence, common exposure to an unidentified environmental source of prions, horizontal transmission of disease, or the presence of unknown shared genetic predisposition.

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