First report of equine parvovirus-hepatitis-associated Theiler's disease in Europe

Equine Veterinary Journal
Modest VengustThomas J Divers

Abstract

Equine parvovirus-hepatitis (EqPV-H) has been proposed as the aetiological cause of Theiler's disease, also known as serum hepatitis. EqPV-H-associated Theiler's disease has not been previously reported in Europe. To determine whether EqPV-H infection was associated with a 2018-2019 outbreak of Theiler's disease in four horses on a studfarm. Descriptive case series. The medical records of four horses from the same farm diagnosed with fatal Theiler's disease were examined retrospectively. Information collected included a clinical history, physical examination findings, tetanus antitoxin exposure, serum biochemistry and necropsy reports. Liver tissue from all four horses was tested for EqPV-H using PCR and in situ hybridisation (ISH) assays. Three of the horses had a history of recent (7-11 weeks) tetanus antitoxin administration. Liver tissue from all four horses tested positive for EqPV-H with PCR. In situ hybridisation revealed a widespread distribution of viral nucleic acid in hepatocytes in one case, and a more sporadic distribution in the remaining three cases. Case controls were not available from the farm in question given the retrospective nature of analysis. This case series documents the first reported EqPV-H-associate...Continue Reading

References

Jan 1, 1971·Equine Veterinary Journal·L R Thomsett
Jan 1, 1996·Clinical Microbiology Reviews·D N Fredricks, D A Relman
Dec 15, 2011·The Journal of Molecular Diagnostics : JMD·Fay WangYuling Luo
Mar 20, 2013·Proceedings of the National Academy of Sciences of the United States of America·Sanjay ChandrianiAmy L Kistler
Apr 19, 2013·Journal of Virology·Amit KapoorW Ian Lipkin
Jul 3, 2013·The Journal of Molecular Diagnostics : JMD·David H SpencerEric J Duncavage
Sep 13, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Stephanie PfaenderEike Steinmann
Jan 13, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Joshua D RamsayRobert H Mealey
Mar 10, 2017·Proceedings of the National Academy of Sciences of the United States of America·Stephanie PfaenderEike Steinmann
Jan 20, 2018·Emerging Infectious Diseases·Thomas J DiversAmit Kapoor
Dec 7, 2018·Journal of Veterinary Internal Medicine·Joy E TomlinsonThomas J Divers
May 24, 2019·Viruses·Toni Luise MeisterEike Steinmann

❮ Previous
Next ❯

Citations

Jun 9, 2021·Equine Veterinary Journal·Anna Sophie RamsauerJessika-M V Cavalleri

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.