First report of NDM-1-producing clinical isolate of Leclercia adecarboxylata in Spain

Diagnostic Microbiology and Infectious Disease
Cristina RiazzoJose María Navarro-Marí

Abstract

We describe the case of NDM-1-producing Leclercia adecarboxylata recovered from the clinical sample of a patient hospitalized for a trauma-related injury to his foot. The isolate was resistant to all beta-lactams, quinolones, trimetroprim-sulfametoxazol, gentamicin and tobramicyn. The blaNDM-1gene was located in a conjugative plasmid that also contained the blaSHV-12gene and was preceded by a disrupted insertion sequence of ISAba125. The plasmid belongs to the incompatibility group X3, which is known to be an important vector for NDM-1 dissemination in China. This is the first reported case of NDM-1L. adecarboxylata in our country and evidences that species of uncertain clinical relevance can act as hidden sources of clinically important resistance determinants.

Citations

Jan 10, 2018·Antimicrobial Agents and Chemotherapy·Pak-Leung HoKin-Hung Chow
Jun 20, 2018·QJM : Monthly Journal of the Association of Physicians·H Matsuura, S Sugiyama
Oct 25, 2017·Letters in Applied Microbiology·M ChoudharyS B Barbuddhe
Dec 24, 2019·Frontiers in Microbiology·Qiaoling SunRong Zhang
Aug 31, 2019·Case Reports in Critical Care·Nooraldin MerzaTarek Naguib

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