First report of pathogenic Leptospira spp. isolated from urine and kidneys of naturally infected cats

PloS One
Abdul Rahman AlashrafMuhammad Sabri Abdul Rahman

Abstract

Leptospirosis is one of the most widespread zoonotic diseases and can infect both humans and animals worldwide. Healthy cat, as a potential source of exposure to humans, are likely underestimated owing to the lack of overt clinical signs associated with Leptospira spp. infection in this species. The aim of the study was to determine the exposure, shedding, and carrier status of leptospires in shelter cats in Malaysia by using serological, molecular, and bacteriological methods. For this study, 82 healthy cats from two shelters were sampled. The blood, urine, and kidneys were tested using the microscopic agglutination test (MAT), polymerase chain reaction (PCR), and bacterial culture. On the basis of serological, molecular, and/or culture techniques, the total detection of leptospiral infection was 29.3% (n = 24/82). Through culture techniques, 16.7% (n = 4/24) of the cats that tested positive were carriers with positive kidney cultures, and one cat was culture positive for both urine and kidney. The Leptospira spp. isolates were identified as pathogenic L. interrogans serovar Bataviae through serological and molecular methods. Through serological techniques, 87.5% (n = 21/24) had positive antibody titers (100-1600) and most of ...Continue Reading

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Citations

Oct 23, 2020·PloS One·Roswitha DorschKatrin Hartmann
Jan 23, 2021·International Journal of Environmental Research and Public Health·Andrea MurilloJosep Pastor
Jan 23, 2021·International Journal of Environmental Research and Public Health·Lucas N PazMelissa H Pinna
Dec 18, 2020·Letters in Applied Microbiology·M I N Di Azevedo, W Lilenbaum
Mar 16, 2021·Journal of Feline Medicine and Surgery·Emilia BourassiSunny Hartwig

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Datasets Mentioned

BETA
MF589180.1
MK391607

Methods Mentioned

BETA
PCR
electrophoresis

Software Mentioned

MEGA7
GelDoc
CLUSTALW
Basic Local Alignment Search Tool ( BLAST )
Alpha imager

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