First report on HLA-DPB1 gene allelic distribution in the general Lebanese population

Genetic Testing and Molecular Biomarkers
Dina ShammaaRami A R Mahfouz

Abstract

Interest in the importance of the HLA-DPB1 gene has increased lately, especially in transplantation outcomes in addition to other HLA CII molecules. This is the first study that assesses HLA-DPB1 typing among healthy Lebanese individuals. The HLA-DPB1 alleles were detected using the polymerase chain reaction/sequence-specific priming method and our study included 130 individuals. HLA-DPB1 was determined in different ethnic groups and in relation to various clinical entities. We compared our data with the existing literature and found an interesting similarity between the Lebanese and Greek populations with highly specific alleles not reported in other communities. Our study will form the basis for further research to study the correlation between HLA-DPB1 and various clinical entities as well as a primer study for other transplantation centers.

References

Jun 1, 1997·Immunological Reviews·J A HansenC Anasetti
Feb 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·G LombardiR Lechler
Apr 12, 2001·British Journal of Haematology·E W PetersdorfJ A Hansen
Mar 25, 2005·Tissue Antigens·S G E MarshJ Trowsdale
Jul 12, 2007·Cancer Immunology, Immunotherapy : CII·Malcolm TaylorUNKNOWN UKCCS Investigators
Jan 16, 2008·Tissue Antigens·Dongmei Wang, Zhixin Zhang

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Citations

Sep 25, 2012·Gene·Sara KhansaRami A R Mahfouz
Sep 22, 2012·Tissue Antigens·Pedro CanoAdlette Inati

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Methods Mentioned

BETA
genotyping
PCR

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