First report on interferon related developmental regulator-1 from Macrobrachium rosenbergii: bioinformatic analysis and gene expression

Fish & Shellfish Immunology
Jesu ArockiarajSubha Bhassu

Abstract

This study reports the first full length gene of interferon related developmental regulator-1 (designated as MrIRDR-1), identified from the transcriptome of Macrobrachium rosenbergii. The complete gene sequence of the MrIRDR-1 is 2459 base pair long with an open reading frame of 1308 base pairs and encoding a predicted protein of 436 amino acids with a calculated molecular mass of 48 kDa. The MrIRDR-1 protein contains a long interferon related developmental regulator super family domain between 30 and 330. The mRNA expressions of MrIRDR-1 in healthy and the infectious hypodermal and hematopoietic necrosis virus (IHHNV) infected M. rosenbergii were examined using qRT-PCR. The MrIRDR-1 is highly expressed in hepatopancreas along with all other tissues (walking leg, gills, muscle, haemocyte, pleopods, brain, stomach, intestine and eye stalk). After IHHNV infection, the expression is highly upregulated in hepatopancreas. This result indicates an important role of MrIRDR-1 in prawn defense system.

References

Aug 13, 1993·Cell·A B Sachs
Oct 6, 1998·Annual Review of Biochemistry·G R StarkR D Schreiber
Jul 30, 1999·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·A Eroshkin, A Mushegian
Sep 7, 2001·Annual Review of Microbiology·G C Sen
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Feb 16, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Betsy BarnesPaula M Pitha
Oct 22, 2004·Nature Immunology·Paul D Bieniasz
Jun 9, 2005·Fish & Shellfish Immunology·Børre Robertsen
Aug 5, 2006·Developmental and Comparative Immunology·Yi-Bing ZhangJian-Fang Gui
Apr 3, 2007·Biochimie·A Paun, P M Pitha
Mar 26, 2009·BioFactors·Volker Fensterl, Ganes C Sen
Dec 15, 2010·Developmental and Comparative Immunology·Guobin HuXianzhi Dong

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.