First results of a ferritin-based blood donor deferral policy in the Netherlands.

Transfusion
Marieke VinkenoogMart P Janssen

Abstract

Whole blood donors are at risk of becoming iron deficient. To monitor iron stores, Sanquin implemented a new deferral policy based on ferritin levels, in addition to the traditional hemoglobin measurements. Ferritin levels are determined in every fifth donation, as well as in all first-time donors. Donors with ferritin levels <15 ng/mL (WHO threshold) are deferred for 12 months; those ≥15 and ≤30 ng/mL for 6 months. The first results were analyzed and are presented here. The results show that 25% of women (N = 20151, 95% CI 24%-25%) and 1.6% of men (N = 10391, 95% CI 1.4%-1.8%) have ferritin levels ≤30 ng/mL at their first blood center visit. For repeat (non-first-time) donors, these proportions are higher: 53% of women (N = 28329, 95% CI 52%-54%) and 42% of men (N = 31089, 95% CI 41%-43%). After a 6-month deferral, in 88% of returning women (N = 3059, 95% CI 87%-89%) and 99% of returning men (N = 3736, 95% CI 98%-99%) ferritin levels were ≥15 ng/mL. After a 12-month deferral, in 74% of returning women (N = 486, 95% CI 70%-78%) and 95% of returning men (N = 479, 95% CI 94%-97%) ferritin levels increased to ≥15 ng/mL. Deferral of donors whose pre-donation ferritin levels were ≤30 ng/mL might prevent donors from returning with fe...Continue Reading

References

Jul 28, 2007·Transfusion·Brian CusterEdward L Murphy
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Dec 16, 2010·Transfusion·Brian CusterUNKNOWN NHLBI Retrovirus Epidemiology Donor Study-II
Jul 6, 2014·The Cochrane Database of Systematic Reviews·Graham A SmithDavid J Roberts
Oct 4, 2014·Frontiers in Microbiology·Gabriele BergKornelia Smalla
Feb 11, 2015·JAMA : the Journal of the American Medical Association·Joseph E KissUNKNOWN National Heart, Lung, and Blood Institute (NHLBI) Recipient Epidemiology and Donor Evaluation Study–III (REDS-III)
Sep 6, 2017·Transfusion·Mindy GoldmanUNKNOWN Biomedical Excellence for Safer Transfusion Collaborative (BEST) Investigators
May 17, 2018·British Journal of Haematology·Joseph E Kiss, Ralph R Vassallo
Jun 9, 2018·Clinical Case Reports·Esa T Soppi
Oct 1, 2019·Transfusion·Saurabh ZalpuriMarian G J van Kraaij

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Citations

Feb 16, 2021·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Salwa HindawiNaima Oumeziane
Jun 2, 2021·Vox Sanguinis·John T BlakeMindy Goldman

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