First steps towards systems radiation biology studies concerned with DNA and chromosome structure within living cells

Radiation and Environmental Biophysics
W FriedlandC Cremer

Abstract

For the understanding of radiation action on biological systems like cellular macromolecules (e.g., DNA in its higher structures) a synergistic approach of experiments and quantitative modelling of working hypotheses is necessary. Further on, the influence on calculated results of certain assumptions in such working hypotheses must critically be evaluated. In the present work, this issue is highlighted in two aspects for the case of DNA damage in single cells. First, yields of double-strand breaks and frequency distributions of DNA fragment lengths after ion irradiation were calculated using different assumptions on the DNA target model. Compared to a former target model now a moderate effect due to the inclusion of a spherical chromatin domain model has been found. Second, the influence of assumptions on particular geometric chromosome models on calculated chromosome aberration data is illustrated with two target-modelling approaches for this end point.

References

Jul 1, 1975·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·D C LloydM J Corp
Nov 13, 1998·Journal of Molecular Biology·B RydbergA Chatterjee
Jun 29, 1999·Radiation and Environmental Biophysics·W FriedlandA Ottolenghi
Mar 25, 2000·Science·B D Michael, P O'Neill
Aug 27, 2002·Radiation Protection Dosimetry·F BallariniA Ottolenghi
Aug 27, 2002·Radiation Protection Dosimetry·M Dingfelder
Feb 26, 2003·Radiation Research·Werner FriedlandMichael Dingfelder
Sep 16, 2003·Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)·F Ballarini, A Ottolenghi
May 27, 2004·Cytogenetic and Genome Research·F Ballarini, A Ottolenghi
Aug 17, 2004·Radiation and Environmental Biophysics·Francesca Ballarini, Andrea Ottolenghi
Jul 13, 2005·Plant Physiology·David L WheelerJames Ostell
Sep 29, 2005·Radiation Research·Francesca Ballarini, Andrea Ottolenghi
Dec 15, 2006·Radiation Protection Dosimetry·Werner FriedlandMarco Liotta

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Citations

Feb 18, 2009·Proceedings of the National Academy of Sciences of the United States of America·B JakobG Taucher-Scholz
Feb 4, 2014·The International Journal of Biochemistry & Cell Biology·Christophe Lavelle, Nicolas Foray
Dec 5, 2014·Medical Physics·Piotr PaterMario A Bernal
Jan 25, 2008·Radiation and Environmental Biophysics·Herwig G Paretzke
Oct 25, 2008·Radiation and Environmental Biophysics·Maximilian S KreiplHerwig G Paretzke
Jul 15, 2009·Radiation and Environmental Biophysics·Maximilian Stephan KreiplHerwig G Paretzke
May 3, 2014·Pharmacology & Therapeutics·Lluís NisaMichaela Medová
Jan 15, 2011·Computer Methods and Programs in Biomedicine·Ziad FrancisIsabelle Clairand
Feb 1, 2015·Radiation Protection Dosimetry·M BellamyK Eckerman
Sep 3, 2010·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Z FrancisC Villagrasa
Apr 20, 2010·Mutation Research·Sylvia Ritter, Marco Durante
Aug 10, 2011·International Journal of Radiation Biology·Werner FriedlandPeter Jacob
Oct 1, 2011·International Journal of Radiation Biology·Daniele AlloniAndrea Ottolenghi
Aug 15, 2014·Radiation Research·D AlloniA Ottolenghi
Apr 12, 2012·Radiation Research·Artem L PonomarevFrancis A Cucinotta
Jun 5, 2015·Mutation Research. Reviews in Mutation Research·K Sankaranarayanan, H Nikjoo
May 11, 2012·Physics in Medicine and Biology·Issam El NaqaJan Seuntjens
Dec 2, 2014·Journal of Physics. Condensed Matter : an Institute of Physics Journal·Jean-Baptiste BouléChristophe Lavelle
Jan 15, 2020·Physics in Medicine and Biology·Stefanos MargisDimitris Emfietzoglou
May 14, 2020·Radiation Research·Hongyu ZhuJan Schuemann
Sep 16, 2020·Radiation Research·Jing TangPengcheng Zhang
Dec 22, 2019·Radiation and Environmental Biophysics·Werner HofmannImre Balásházy
Oct 19, 2016·Reports on Progress in Physics·H NikjooS Uehara
Nov 21, 2020·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Wei TangLiang Sun
Sep 13, 2019·Clinical Oncology : a Journal of the Royal College of Radiologists·M A Hill

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