First three reported cases of nosocomial fungemia caused by Candida auris.

Journal of Clinical Microbiology
Wee Gyo LeeHee-Chang Jang

Abstract

Candida auris is a newly described species whose clinical significance is not clear. Here, we describe the first three cases of nosocomial fungemia caused by C. auris, which confirms that it is a causative agent of bloodstream infections. All three patients presented persistent fungemia for 10 to 31 days. The isolates obtained from the three patients were misidentified as Candida haemulonii and Rhodotorula glutinis by the Vitek 2 and the API 20C systems, respectively. C. auris was confirmed by sequence analysis of the internal transcribed spacer region and D1/D2 regions of the 26S ribosomal DNA of the rRNA gene. The MIC ranges of amphotericin B (AMB), fluconazole (FLU), itraconazole, and voriconazole were 0.5 to 1, 2 to 128, 0.125 to 2, and 0.06 to 1 μg/ml, respectively. All isolates were susceptible to caspofungin (MIC = 0.06 μg/ml) and micafungin (MIC = 0.03 μg/ml). One patient developed breakthrough fungemia while receiving FLU therapy, and two patients who received FLU therapy followed by AMB showed therapeutic failure and fatal outcomes. Our cases show that C. auris fungemia can be persistent, despite FLU or AMB therapy, which emphasizes the importance of accurately identifying this species.

References

Jan 8, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Juergen Loeffler, David A Stevens
Jul 29, 2005·Antimicrobial Agents and Chemotherapy·Cornelius J ClancyM Hong Nguyen
Feb 6, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mi-Na KimDong Wook Ryang
Apr 16, 2010·Medical Mycology·Sook-In JungUNKNOWN Korean Study Group for Candidemia

❮ Previous
Next ❯

Citations

Sep 21, 2013·Emerging Infectious Diseases·Anuradha ChowdharyJacques F Meis
Mar 20, 2013·Indian Journal of Medical Microbiology·S SarmaA Rattan
Jun 26, 2014·Emerging Infectious Diseases·Rindidzani E MagoboNelesh P Govender
Dec 21, 2013·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·A ChowdharyJ F Meis
Nov 10, 2015·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Anupam PrakashAnuradha Chowdhary
Sep 9, 2015·BMC Genomics·Sharanya ChatterjeeUtpal S Tatu
May 20, 2015·Emerging Infectious Diseases·Maha EmaraRitu Bafna
Oct 10, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M C ArendrupUNKNOWN European Confederation of Medical Mycology
Jul 28, 2016·The Journal of Infection·Belinda CalvoArnaldo Lopes Colombo
Sep 17, 2016·The Journal of Hospital Infection·A ChowdharyJ F Meis
Oct 26, 2016·Antimicrobial Resistance and Infection Control·Silke SchelenzMatthew C Fisher
Jul 15, 2016·International Journal of Systematic and Evolutionary Microbiology·Matthias Sipiczki, Ratna Mohd Tap
Dec 29, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S VallabhaneniT M Chiller
Dec 19, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Cornelius J Clancy, M Hong Nguyen
Dec 9, 2016·Expert Review of Anti-infective Therapy·H M H N BandaraL P Samaranayake
Jan 31, 2017·Revista iberoamericana de micología·Alba Cecilia Ruiz GaitánJavier Pemán
Apr 6, 2017·Mycoses·Hyoung Il ChoiJun Seong Son
May 19, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Marwan M AzarVirginia M Pierce
Jul 8, 2017·Mycoses·Jalila MohsinAbdullah M S Al-Hatmi
Mar 30, 2018·Emerging Microbes & Infections·Johanna RhodesSilke Schelenz
Mar 31, 2018·Antimicrobial Resistance and Infection Control·Marie-Elisabeth BougnouxJean-Ralph Zahar
May 16, 2018·Annals of the New York Academy of Sciences·Jennifer Geddes-McAlister, Rebecca S Shapiro
Nov 22, 2017·Antimicrobial Agents and Chemotherapy·Ruvini U PathiranaMira Edgerton
Apr 4, 2018·Antimicrobial Agents and Chemotherapy·Virginia BassoMichael E Selsted
Apr 11, 2018·Antimicrobial Agents and Chemotherapy·Milena KordalewskaDavid S Perlin
Nov 17, 2017·Clinical Microbiology Reviews·Anna Jeffery-SmithColin S Brown
Jun 8, 2018·Current Opinion in Infectious Diseases·Katja SarisAndreas Voss
Nov 24, 2017·Journal of Clinical Microbiology·Emily S Spivak, Kimberly E Hanson
Jun 7, 2017·Antimicrobial Agents and Chemotherapy·Alexander J LepakDavid R Andes
Oct 4, 2018·The New England Journal of Medicine·David W EyreKatie J M Jeffery

❮ Previous
Next ❯

Related Concepts

Related Feeds

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.