First trimester concentrations of the TTR-RBP4-retinol complex components as early markers of insulin-treated gestational diabetes mellitus

Clinical Chemistry and Laboratory Medicine : CCLM
Arrigo FruscalzoJens Raila

Abstract

The objective of the study was to investigate the relationship between first trimester maternal serum levels of the TTR-RBP4-ROH complex components and the later insurgence of an altered glucose metabolism during pregnancy. Retrospective case control study including 96 patients between the 12th and 14th week of gestation, 32 that developed gestational diabetes mellitus (GDM), respectively, 21 non-insulin-treated (dGDM) and 11 insulin-treated (iGDM), 20 large for gestational age fetuses (LGA) without GDM and 44 patients with normal outcome as control. Serum concentrations of RBP4 and TTR were assessed by ELISA; serum concentration of ROH by reverse-phase high performance liquid chromatography (rpHPLC). The molecular heterogeneity of TTR and RBP4 was analyzed after immunoprecipitation by matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF-MS). iGDM patients were characterized by reduced TTR, RBP4 and ROH compared to controls (respectively, iGDM vs. controls, mean±SD: TTR 3.96±0.89 μmol/L vs. 4.68±1.21 μmol/L, RBP4 1.13±0.25 μmol/L vs. 1.33±0.38 μmol/L and ROH 1.33±0.17 μmol/L vs. 1.62±0.29 μmol/L, p<0.05). TTR containing Gly10 in place of Cys10 was lower in the iGDM group (p<0.05) compared to c...Continue Reading

References

Aug 1, 1989·The American Journal of Clinical Nutrition·T K BasuJ Leichter
Jan 1, 1994·Annual Review of Nutrition·Y Ingenbleek, V Young
Sep 18, 1997·Nutrition·T K Basu, C Basualdo
Jan 29, 2000·The American Journal of Clinical Nutrition·V SapinV Azaïs-Braesco
Oct 19, 2000·The Journal of Biological Chemistry· van Bennekum AMW S Blaner
Jan 6, 2007·Journal of Proteome Research·Carlo VascottoFranco Quadrifoglio
Sep 1, 2007·Translational Research : the Journal of Laboratory and Clinical Medicine·Oussama GrissaNaim Akhtar Khan
Sep 27, 2008·Rapid Communications in Mass Spectrometry : RCM·Andrea HenzeFlorian J Schweigert
Apr 9, 2009·Journal of Nutritional Science and Vitaminology·Yong-Zhong WangGuo-Yuan Zhang
Jan 26, 2010·Biochemical and Biophysical Research Communications·Andrea HenzeFlorian J Schweigert
Feb 9, 2010·Cellular and Molecular Life Sciences : CMLS·Maria TheodosiouMichael Schubert
Apr 15, 2010·Hormone Research in Pædiatrics·D YesteA Carrascosa
Dec 1, 2010·Best Practice & Research. Clinical Obstetrics & Gynaecology·Christopher J Nolan
Mar 4, 2011·Proceedings of the National Academy of Sciences of the United States of America·Daniel C BerryNoa Noy
Jul 12, 2011·Metabolism: Clinical and Experimental·Weerapan KhovidhunkitThipaporn Tharavanij
Dec 30, 2011·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·G A ChristouD N Kiortsis
Apr 24, 2012·Metabolism: Clinical and Experimental·Viroj Wiwanitkit
Oct 2, 2012·Cell·Trevor D LittlewoodGerard I Evan
Nov 17, 2012·Diabetes Research and Clinical Practice·Dejene F AbetewDaniel A Enquobahrie
Dec 20, 2012·Antioxidants & Redox Signaling·Andrea HenzeFlorian J Schweigert
Jan 29, 2013·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Arrigo FruscalzoFrancesco Curcio
Feb 16, 2013·Metabolism: Clinical and Experimental·Surabhi NandaKypros H Nicolaides
Feb 22, 2013·Journal of Pediatric Endocrinology & Metabolism : JPEM·Daniela OliveiraRúben Fernandes
Mar 29, 2013·Clinical Chemistry·Donald R Coustan
Jun 19, 2013·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Ambrogio P LonderoDiego Marchesoni
Aug 22, 2013·The Journal of the Egyptian Public Health Association·Hayfaa A WahabiRasmieh A Alzeidan
Sep 25, 2014·Archives of Gynecology and Obstetrics·A FruscalzoL Driul

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Citations

Jul 29, 2015·Journal of Proteomics·Apoorva SinghKoel Chaudhury
Jan 2, 2018·World Journal of Diabetes·AbdelHameed Mirghani Dirar, John Doupis
May 27, 2020·Archives of Gynecology and Obstetrics·Mengting LiuDanqing Chen
Jul 25, 2019·BMC Pregnancy and Childbirth·Ambrogio P LonderoLorenza Driul
Jul 30, 2020·Journal of Diabetes Research·Tao ZhouShi-Wen Jiang
Nov 20, 2019·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Arrigo FruscalzoLaura Mariuzzi

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