First-trimester fetal heart rate in mothers with opioid addiction

Addiction
Maximilian SchmidElisabeth Krampl-Bettelheim

Abstract

To investigate the difference in fetal heart rate of opioid-dependent mothers compared to non-dependent mothers in the first trimester of pregnancy. The data of 74 consecutive singleton pregnancies of mothers enrolled in a maintenance programme for opioid-dependent women was matched to 74 non-exposed singleton pregnancies by maternal age, crown-rump length, smoking status, ethnic background and mode of conception. Fetal heart rate measured as part of first-trimester screening by Doppler ultrasound between 11+0 and 13+6 gestational weeks was compared retrospectively. The mean fetal heart rate in opioid-dependent mothers was 156.0 beats per minute (standard deviation 7.3) compared to 159.6 (6.5) in controls. The difference in fetal heart rate was significant (P = 0.02). There was a significant difference in mean maternal body mass index (P = 0.01) but not in mean nuchal translucency (P = 0.3), gestational age (0.5), fetal gender (P = 0.3) and parity (P = 0.3) between both groups. Fifty-five per cent (41 of 74) of cases were taking methadone, 30% (22 of 74) buprenorphine and 15% (11 of 74) were taking slow-release morphines throughout the pregnancy. In fetuses of opioid-dependent mothers a decreased fetal heart rate can already be...Continue Reading

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Citations

Jan 23, 2013·Clinical Obstetrics and Gynecology·Ellen Kopel, Washington C Hill
Jan 1, 2013·International Journal of High Risk Behaviors & Addiction·Iraj SahramianElham Sharafi
May 23, 2014·Obstetrics and Gynecology Clinics of North America·Luis A Izquierdo, Nicole Yonke
Nov 1, 2012·Addiction·Amy L SalisburyHendrée E Jones
Apr 2, 2017·Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC·Gareth RyanLen Kelly
Aug 7, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Bobby BrarPetar Planinic
Feb 26, 2021·Medicina clínica·Carla Sans-PolaCristina Aguilera

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