First trimester invasive procedures: effects on symptom status and lung volume in very young children

Pediatric Pulmonology
A GreenoughK H Nicolaides

Abstract

First trimester procedures have been associated with perinatal lung function abnormalities that may suggest subsequent respiratory problems. Our aim was, therefore, to assess the impact of first trimester invasive procedures [early amniocentesis (EA) and chorion villus sampling (CVS)] on respiratory morbidity in very young children. A questionnaire was issued to parents of 439 EA and 453 CVS (subjects), and 435 controls (their mothers had undergone no invasive procedures) when their children were one year old. Data were also obtained from diary cards issued to a subset of 278 of the EA, 262 of the CVS, and 264 of the control infants followed prospectively. Functional residual capacity (FRC) was measured at a median age of 5 months (range: 0.25-24) in 159 children whose mothers had undergone EA, 168 following CVS and in 165 controls. Analysis of the one-year questionnaire demonstrated an excess of symptomatic infants in the EA group (31%) compared to the CVS (22%; P < 0.01) and control groups (17%; P < 0.01). Findings from the prospective follow-up study confirmed those results and also demonstrated an increase in chest-related hospital admissions in the EA group (3%) compared to the controls (0.4%; P < 0.05). Logistic regressio...Continue Reading

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Citations

Dec 27, 2005·The Pediatric Infectious Disease Journal·Anne Greenough, Simon Broughton
Mar 22, 2005·BJOG : an International Journal of Obstetrics and Gynaecology·Maria CederholmOve Axelsson
Jan 10, 2018·Pediatric Pulmonology·Jessica LoAnne Greenough

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