First-trimester levels of pregnancy-associated plasma protein A2 (PAPP-A2) in the maternal circulation are elevated in pregnancies that subsequently develop preeclampsia

Reproductive Sciences
Erin J CrosleyJulian K Christians

Abstract

Recent studies have consistently found pregnancy-associated plasma protein A2 (PAPP-A2) to be upregulated in preeclamptic placentae at term. We tested whether first-trimester circulating PAPP-A2 levels differed between complicated and uncomplicated pregnancies. We measured maternal PAPP-A2 levels at 10 to 14 weeks of gestational age in 17 pregnancies resulting in small-for-gestational-age (SGA) infants, 6 which developed preeclampsia (PE), 1 which developed PE and resulted in an SGA infant, and 37 gestational age-matched controls. The concentration of the PAPP-A2 isoform corresponding to the full-length protein was significantly higher in pregnancies that developed PE (35 ng/mL) compared with those that did not (23 ng/mL; P < .044). In contrast, we found no difference in PAPP-A2 levels between pregnancies that did or did not result in an SGA infant. The upregulation of PAPP-A2 that has previously been observed in PE at term appears to begin early in pregnancy, well before the symptoms develop.

References

Nov 5, 1998·Journal of Molecular Endocrinology·L J Murphy
May 29, 2000·American Journal of Physiology. Endocrinology and Metabolism·R C Baxter
Oct 6, 2000·Biochimica Et Biophysica Acta·M FarrH Tschesche
Apr 30, 2002·Placenta·Keith M Godfrey
Apr 26, 2003·Trends in Endocrinology and Metabolism : TEM·R Clay Bunn, John L Fowlkes
Dec 18, 2003·Acta Obstetricia Et Gynecologica Scandinavica·Nick A Bersinger, Rønnaug A Ødegård
Jun 11, 2005·Science·Christopher W Redman, Ian L Sargent
Jul 26, 2006·Gynecologic and Obstetric Investigation·Marcel ZwahlenNick A Bersinger
Jan 16, 2007·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Henning B Boldt, Cheryl A Conover
Apr 1, 2008·Placenta·M BuimerC Ris-Stalpers
Apr 5, 2008·Current Opinion in Obstetrics & Gynecology·Peter von Dadelszen, Laura Magee
Apr 5, 2008·Current Opinion in Obstetrics & Gynecology·Wendy L Kinzler, Anthony M Vintzileos
Sep 23, 2008·Molecular Human Reproduction·Haruki NishizawaYasuhiro Udagawa
May 26, 2009·Seminars in Perinatology·Peter von DadelszenUNKNOWN PIERS (Pre-eclampsia Integrated Estimate of RiSk) Study Group
May 29, 2009·The Journal of Endocrinology·Joyce WangJulian K Christians
Jul 21, 2010·Reproductive Biology and Endocrinology : RB&E·Pamela K Wagner, Julian K Christians
Oct 6, 2010·The Journal of Physiology·A N Sferruzzi-PerriC T Roberts
Apr 19, 2011·Reproductive Biology and Endocrinology : RB&E·Pamela K WagnerJulian K Christians
Aug 26, 2011·The Journal of Clinical Endocrinology and Metabolism·Premila PaivaStephen Tong
Jan 23, 2013·The Journal of Clinical Endocrinology and Metabolism·Clare L WhiteheadStephen Tong

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Citations

Sep 30, 2015·Cell Adhesion & Migration·Julian K Christians, Alexander G Beristain
Dec 15, 2015·Proceedings of the National Academy of Sciences of the United States of America·Amy L WinshipEvdokia Dimitriadis
Sep 30, 2015·Reproductive Biology and Endocrinology : RB&E·Julian K ChristiansSonia M Hessels
Jul 15, 2015·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Julian K ChristiansNeilab Amiri
Dec 6, 2014·Reproductive Biology and Endocrinology : RB&E·Erin J CrosleyJulian K Christians
Jul 25, 2019·Diabetic Medicine : a Journal of the British Diabetic Association·J DerekeM Hillman
Jan 30, 2020·Reproductive Sciences·Leah M Lamale-SmithLorna G Moore
Dec 21, 2019·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Bridget DiPriscoChristos S Mantzoros
Nov 7, 2015·Clinical Chemistry and Laboratory Medicine : CCLM·Young Bae HansenSteen Sørensen
Sep 30, 2020·Journal of the American Heart Association·Rugina I NeumanA H Jan Danser
Jun 14, 2018·Reproductive Biology and Endocrinology : RB&E·Julian K ChristiansNimrat Binning

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Methods Mentioned

BETA
SGA
enzyme-linked immunosorbent assay
glycosylation
ELISA

Software Mentioned

Odyssey Infrared Imaging System Application

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