Abstract
To investigate whether combined first-trimester screening (cFTS) biomarkers are associated with cerebral palsy (CP) and to identify CP characteristics associated with abnormal biomarker levels. In this retrospective case-control data linkage study, we matched mothers of 435 singletons with CP from a population register to their cFTS records and selected 10 singleton pregnancy controls per case. We compared mean and abnormal levels (expressed as multiples of the median [MoMs]) of pregnancy-associated plasma protein-A (PAPP-A), beta subunit of human chorionic gonadotrophin (β-hCG), and nuchal translucency between cases and controls and between CP subgroups. Compared with control pregnancies, CP pregnancies had lower mean levels of PAPP-A (0.95 vs 1.01 MoM, p=0.02) and β-hCG (0.93 vs 0.99 MoM, p=0.02). Biomarker levels in CP pregnancies were 1.8 times more likely to be associated with abnormally low levels of PAPP-A (p<0.01), 1.4 times for β-hCG (p=0.12), and 2.6 times for low PAPP-A and β-hCG together (p=0.04). In cases with CP, an abnormally low PAPP-A level was associated with moderate preterm birth, low Apgar scores, and Gross Motor Function Classification System level V. Low β-hCG was associated with very low birthweight. Low...Continue Reading
References
Apr 1, 1997·Developmental Medicine and Child Neurology·R PalisanoB Galuppi
Aug 6, 2004·American Journal of Obstetrics and Gynecology·Kypros H Nicolaides
May 16, 2007·BJOG : an International Journal of Obstetrics and Gynaecology·A M JaquesL J Sheffield
Jul 20, 2007·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Raymond W RedlineMaureen Hack
Oct 27, 2007·Taiwanese Journal of Obstetrics & Gynecology·Bo-Quing SheMing-Song Tsai
Jun 12, 2008·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Raymond W Redline
Aug 6, 2008·BMC Pregnancy and Childbirth·Rachel K MorrisKhalid S Khan
Jan 10, 2009·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Kate J BrameldRosanne Stock
Aug 4, 2009·American Journal of Obstetrics and Gynecology·Stefano UccellaPierfrancesco Bolis
Jan 21, 2010·Prenatal Diagnosis·Katherine R GoetzingerAnthony O Odibo
Sep 10, 2010·Prenatal Diagnosis·R van RavenswaaijP C J I Schielen
Jul 5, 2011·American Journal of Obstetrics and Gynecology·Eve BlairKarin B Nelson
Oct 25, 2011·Prenatal Diagnosis·Ida KirkegaardTine B Henriksen
Jul 10, 2012·Fertility and Sterility·Anne EskildTom G Tanbo
Jan 26, 2013·Developmental Medicine and Child Neurology·Maryam OskouiTamara Pringsheim
Feb 12, 2013·American Journal of Obstetrics and Gynecology·Laura L Jelliffe-PawlowskiJeffrey B Gould
Jan 17, 2014·Developmental Medicine and Child Neurology·Susan M ReidDinah S Reddihough
Mar 14, 2014·Developmental Medicine and Child Neurology·Håvard TrønnesDag Moster
Jan 1, 2014·Journal of Clinical Medicine·Howard Cuckle
Sep 15, 2015·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·P SirikunalaiT Tongsong
Jan 15, 2016·Developmental Medicine and Child Neurology·Susan M ReidUNKNOWN Australian Cerebral Palsy Register Group
Sep 22, 2016·Journal of the Turkish German Gynecological Association·Ayşe Filiz AvşarAhmet Ferit Dalgacı
Dec 25, 2016·Prenatal Diagnosis·R Katie MorrisMark D Kilby
Oct 21, 2017·Obstetric Medicine·Marina S GomesPaula Pinheiro
May 21, 2018·Archives of Gynecology and Obstetrics·Santee TiyathaTheera Tongsong
Jul 15, 2018·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Anne EskildKari Kveim Lie
Sep 11, 2018·Prenatal Diagnosis·Xavier-Côme DonatoRaoul Desbriere
Oct 30, 2018·The Journal of Pediatrics·Torstein VikMaryam Oskoui
Jul 28, 2019·American Journal of Obstetrics and Gynecology·Jessica M TurnerSailesh S Kumar