First trimester preeclampsia screening and prediction

American Journal of Obstetrics and Gynecology
Piya ChaemsaithongLiona C Poon

Abstract

Preeclampsia is a major cause of maternal and perinatal morbidity and mortality. Early onset disease requiring preterm delivery is associated with a higher risk of complications in both mothers and babies. Evidence suggests that the administration of low dose aspirin initiated prior to 16 weeks' gestation significantly reduces the rate of preterm preeclampsia. Therefore, it is important to identify pregnant women at risk of developing preeclampsia during the first trimester of pregnancy, thus allowing timely therapeutic intervention. Several professional organizations such as American College of Obstetricians and Gynecologists (ACOG) and National Institute for Health and Care Excellence (NICE) have proposed screening for preeclampsia based on maternal risk factors. The approach recommended by the ACOG and NICE essentially treats each risk factor as a separate screening test with additive detection rate and screen positive rate. Evidence has shown that preeclampsia screening based on the NICE and ACOG approach has suboptimal performance as the NICE recommendation only achieves detection rates of 41% and 34%, at 10% false positive rate, for preterm and term preeclampsia, respectively. Screening based on the ACOG (2013) recommenda...Continue Reading

Citations

Jan 22, 2021·Reproductive Sciences·А О KarapetianG T Sukhikh
Jan 27, 2021·Diabetes Care·Claire L MeekUNKNOWN CONCEPTT Collaborative Group
Feb 24, 2021·Current Opinion in Obstetrics & Gynecology·Andrew R MatherLoralei L Thorburg
Oct 24, 2020·American Journal of Obstetrics and Gynecology·Sarosh RanaS Ananth Karumanchi
May 16, 2021·American Journal of Obstetrics & Gynecology MFM·Gabriel A ArenasSarosh Rana
Jul 3, 2021·International Journal of Environmental Research and Public Health·Agnieszka MarekAgnieszka Drosdzol-Cop
May 13, 2021·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Petar CabunacŽeljko Miković
Oct 30, 2021·JAMA Network Open·Tamar KrishnamurtiHyagriv N Simhan

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