First trimester pregnancy-associated plasma protein-A and birth weight

European Journal of Obstetrics, Gynecology, and Reproductive Biology
Rebecca J BaerLaura L Jelliffe-Pawlowski

Abstract

To evaluate first trimester pregnancy-associated plasma protein-A (PAPP-A) and birth weight percentile. Included were women who underwent first trimester prenatal screening through the California Prenatal Screening Program with expected dates of delivery between August 2009 and December 2010, linked birth certificate and hospital discharge records, known birth weight, and no chromosomal abnormality (n=134.105). PAPP-A results were reported as multiples of the median. The frequency of small or large for gestational age (SGA, ≤10%; LGA, ≥90%) versus appropriately grown for gestational age birth was examined by PAPP-A percentile. Patterns were studied by gestational age at delivery. Relative risks (RRs) and their 95% confidence intervals were adjusted for race/ethnicity. Women with PAPP-A ≤10th percentile and an infant born after 32 weeks were increasingly more likely to have an SGA infant (adjRRs 1.5-4.6) as the PAPP-A percentile declined, and were increasingly less like to have an LGA infant born at term (adjRRs 0.5-0.7) compared to women with PAPP-A measurement >10th to <90th percentile. PAPP-A ≥90th percentile was protective for SGA among infants born after 32 weeks gestation (adjRRs 0.3-0.7) and was associated with LGA among ...Continue Reading

References

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Feb 12, 2013·American Journal of Obstetrics and Gynecology·Laura L Jelliffe-PawlowskiJeffrey B Gould

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Citations

Jan 29, 2019·Acta Obstetricia Et Gynecologica Scandinavica·Hanna ÅmarkMartina Persson
Oct 30, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Weerawich PornwattanakrilertTheera Tongsong
Sep 29, 2017·Journal of Medical Internet Research·Dorien LanssensWilfried Gyselaers
Aug 11, 2019·The Journal of Pediatrics·Martina A SteurerLaura L Jelliffe-Pawlowski
Jul 21, 2021·Cephalalgia : an International Journal of Headache·Isabella NeriFabio Facchinetti
Sep 26, 2021·BMC Pregnancy and Childbirth·Francesca MonariFabio Facchinetti

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