First-trimester screening for trisomy 21 by free beta-human chorionic gonadotropin and pregnancy-associated plasma protein-A: impact of maternal and pregnancy characteristics

Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology
K O KaganK H Nicolaides

Abstract

To use multiple regression analysis to define the contribution of maternal variables that influence the measured concentration of free beta-human chorionic gonadotropin (beta-hCG) and pregnancy-associated plasma protein-A (PAPP-A), and the interaction between these covariates, in first-trimester biochemical screening for trisomy 21. This was a multicenter study of prospective screening for trisomy 21 by a combination of fetal nuchal translucency thickness, and maternal serum free beta-hCG and PAPP-A at 11 + 0 to 13 + 6 weeks of gestation. In the pregnancies subsequently found to have trisomy 21 and in those with no obvious chromosomal abnormality, we used multiple regression analysis to account for pregnancy characteristics that influence the measured concentrations of free beta-hCG and PAPP-A. We fitted Gaussian distributions to the distribution of log multiples of the median (MoM) values in trisomy 21 and in unaffected pregnancies. There were 491 cases of trisomy 21 and 96 803 chromosomally normal pregnancies. Compared with values in Caucasian women, those who were parous, non-smokers and those who conceived spontaneously, PAPP-A was 57% higher in women of Afro-Caribbean origin, 3% higher in South Asians, 9% higher in East As...Continue Reading

References

Sep 1, 1975·British Journal of Obstetrics and Gynaecology·H P Robinson, J E Fleming
May 26, 1999·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·K SpencerK H Nicolaides
Mar 1, 2005·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·K H NicolaidesO Falcon
Jun 23, 2005·American Journal of Obstetrics and Gynecology·Kyriaki AvgidouKypros H Nicolaides
Nov 2, 2006·Obstetrics and Gynecology·Jacob A CanickUNKNOWN First and Second Trimester Evaluation of Risk (FASTER) Trial Research Consortium

❮ Previous
Next ❯

Citations

Dec 26, 2001·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Patrick DumpsPaul Bischof
Feb 18, 2012·Journal of Human Hypertension·C K H YuK H Nicolaides
Dec 1, 2009·Human Reproduction·Jenni K RantaSeppo Heinonen
Mar 19, 2011·Current Opinion in Obstetrics & Gynecology·Annegret GeipelChristoph Berg
Jan 27, 2011·Fetal Diagnosis and Therapy·Surabhi NandaKypros H Nicolaides
Jul 21, 2012·PloS One·Radek BukowskiMary E D'Alton
Nov 26, 2010·Clinical Chemistry and Laboratory Medicine : CCLM·Henriette P SennelsSteen Sørensen
Feb 6, 2014·Archives of Gynecology and Obstetrics·Markus HoopmannKarl Oliver Kagan
Jan 1, 2014·Journal of Clinical Medicine·Padmalatha GurramWinston Campbell
Aug 20, 2014·Obstetrics and Gynecology International·Leona C Poon, Kypros H Nicolaides
May 5, 2009·Prenatal Diagnosis·Ranjit AkolekarKypros H Nicolaides
Jun 16, 2009·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·K O KaganK H Nicolaides
Feb 27, 2009·Prenatal Diagnosis·Leona C Y PoonKypros H Nicolaides
May 2, 2009·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·K O KaganK H Nicolaides
Jun 3, 2008·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·M BorensteinK H Nicolaides
Aug 30, 2008·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·K O KaganK H Nicolaides
Oct 29, 2008·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·R AkolekarK H Nicolaides
Mar 12, 2009·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·E ZaragozaK H Nicolaides
May 15, 2012·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·A KhalilK H Nicolaides
Jan 21, 2012·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·K O KaganD Wright
Mar 15, 2011·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·D WrightK O Kagan
Jul 27, 2010·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·D WrightK H Nicolaides
Jul 19, 2012·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·C EkelundA Tabor
May 27, 2010·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·K O KaganK H Nicolaides
Jan 7, 2010·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·D S SahotaT K Lau
May 9, 2012·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·A KhalilK H Nicolaides
Jun 13, 2012·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·S BallUNKNOWN Danish Fetal Medicine Study Group
Nov 11, 2010·BJOG : an International Journal of Obstetrics and Gynaecology·M D SavvidouK H Nicolaides
Sep 25, 2009·Prenatal Diagnosis·Ranjit AkolekarKypros H Nicolaides
Jan 29, 2013·Prenatal Diagnosis·Kevin Spencer, Nicholas J Cowans
Mar 16, 2012·Prenatal Diagnosis·Ilkka Y JärveläAydin Tekay
Mar 18, 2011·Prenatal Diagnosis·Srividhya SankaranKevin Spencer
Mar 17, 2010·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·L C Y PoonK H Nicolaides

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.