First trimester ultrasonographic diagnosis of fetal structural abnormalities in a low risk population

British Journal of Obstetrics and Gynaecology
D L Economides, J M Braithwaite

Abstract

Ultrasonographic screening between 12(+0) and 13(+6) weeks for fetal structural abnormalities using transabdominal sonography and, where necessary, transvaginal sonography in a low risk population. A prospective observational study. London teaching hospital. Pregnant women with a total of 1632 low risk viable fetuses between 12(+0) and 13(+6) weeks of gestation were scanned using transabdominal and, where necessary, transvaginal sonography (40%). If the anatomical survey was normal, the women underwent routine 18-20 week anomaly scans. Pregnancy outcomes were obtained from radiological and neonatal computerised databases, and postal or telephone patient enquiry. Seventeen (1.0%) major structural abnormalities were diagnosed in the study group. Of these, 11 (64.7%) were diagnosed at the 12-13 week scan, three diagnosed in the mid-trimester and three postnatally. Of the fetal abnormalities diagnosed antenatally, 78.6% were diagnosed in the first trimester. The sensitivity of abnormality detection by the combination of both first and second trimester scans was 82.3%. In addition, a significant number of missed abortions (n = 36) were also diagnosed by the first trimester scan. This study has demonstrated the potential of screening...Continue Reading

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