First validation of myocardial flow reserve assessed by dynamic 99m Tc-sestamibi CZT-SPECT camera: head to head comparison with 15 O-water PET and fractional flow reserve in patients with suspected coronary artery disease. The WATERDAY study

European Journal of Nuclear Medicine and Molecular Imaging
Denis AgostiniAlain Manrique

Abstract

We assessed the feasibility of myocardial blood flow (MBF) and flow reserve (MFR) estimation using dynamic SPECT with a novel CZT camera in patients with stable CAD, in comparison with 15O-water PET and fractional flow reserve (FFR). Thirty patients were prospectively included and underwent FFR measurements in the main coronary arteries (LAD, LCx, RCA). A stenosis ≥50% was considered obstructive and a FFR abnormal if ≤0.8. All patients underwent a dynamic rest/stress 99mTc-sestamibi CZT-SPECT and 15O-water PET for MBF and MFR calculation. Net retention kinetic modeling was applied to SPECT data to estimate global uptake values, and MBF was derived using Leppo correction. Ischemia by PET and CZT-SPECT was considered present if MFR was lower than 2 and 2.1, respectively. CZT-SPECT yielded higher stress and rest MBF compared to PET for global and LAD and LCx territories, but not in RCA territory. MFR was similar in global and each vessel territory for both modalities. The sensitivity, specificity, accuracy, positive and negative predictive value of CZT-SPECT were, respectively, 83.3, 95.8, 93.3, 100 and 85.7% for the detection of ischemia and 58.3, 84.6, 81.1, 36.8 and 93% for the detection of hemodynamically significant stenosis ...Continue Reading

References

Oct 1, 1984·Circulation·S R BergmannB E Sobel
Jul 21, 1998·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·H Iida, S Eberl
Jan 29, 2003·European Journal of Nuclear Medicine and Molecular Imaging·Yoshinori ItoNagara Tamaki
May 29, 2007·Journal of the American College of Cardiology·Nico H J PijlsBernard de Bruyne
Jul 10, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Mireille LortieRobert A DeKemp
Jan 19, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Hidehiro IidaHiroshi Watabe
Sep 4, 2008·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Michael G Stabin
Jan 16, 2009·The New England Journal of Medicine·Pim A L ToninoUNKNOWN FAME Study Investigators
May 2, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Sergey V NesterovJuhani Knuuti
Jun 16, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Paolo G Camici, Ornella E Rimoldi
Jun 1, 2011·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Stefania DanieleAlberto Cuocolo
Sep 20, 2011·Circulation. Cardiovascular Imaging·Sami A KajanderJuhani Knuuti
Aug 29, 2012·The New England Journal of Medicine·Bernard De BruyneUNKNOWN FAME 2 Trial Investigators
Apr 13, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Simona Ben-HaimMarcelo F Di Carli
May 10, 2013·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Jennifer M RenaudRobert A DeKemp
Jan 11, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Masanao NayaMarcelo F Di Carli
Sep 6, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·R Glenn WellsTerrence D Ruddy
Oct 5, 2014·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Ran KleinBailing Hsu
Aug 19, 2015·European Journal of Nuclear Medicine and Molecular Imaging·Stéphane TuffierAlain Manrique
Sep 5, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Fayçal Ben BouallègueDenis Mariano-Goulart
Sep 26, 2015·JACC. Cardiovascular Interventions·Julien AdjedjBernard De Bruyne
Jun 11, 2016·Journal of the American College of Cardiology·Nils P JohnsonViviany R Taqueti
Jul 2, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Rene NkoulouPhilipp A Kaufmann

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Citations

Feb 7, 2019·Physics in Medicine and Biology·Jing Wu, Chi Liu
Aug 28, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Yuka OtakiDenis Agostini
Feb 21, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Rongzheng MaWei Fang
Mar 18, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Xiao-Ying XiWei Fang
May 2, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Matthieu Pelletier-Galarneau, Terrence D Ruddy
Jun 9, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Riccardo Liga, Alessia Gimelli
Jun 22, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Ana Carolina do A H de SouzaRonaldo S L Lima
Jul 11, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Emilia ZampellaAlberto Cuocolo
Sep 7, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Piotr Slomka
Sep 20, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Matthieu Pelletier-Galarneau, Terrence D Ruddy
Mar 9, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Konstantin V ZavadovskyAlessia Gimelli
Jun 4, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Francesco NudiOrazio Schilllaci
Jan 31, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·A KrakovichR Goldkorn
Feb 7, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Riccardo Liga, Alessia Gimelli
Dec 19, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Wanda AcampaAlberto Cuocolo
Apr 26, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Quentin BranaMatthieu Bailly
Aug 27, 2018·European Journal of Nuclear Medicine and Molecular Imaging·Fabien HyafilDominique Le Guludec
Dec 24, 2018·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Fabien HyafilDominique Le Guludec
Aug 26, 2018·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Brian G AbbottR Glenn Wells
Jun 15, 2019·Circulation. Cardiovascular Imaging·Michael Jerosch-Herold, Piotr Slomka
Apr 10, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Gabriel Blacher Grossman
Nov 16, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Raffaele GiubbiniLuca Camoni
Feb 23, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Matthieu BaillyMaria Joao Ribeiro
May 28, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Kenichi Nakajima, Hiroshi Wakabayashi
Apr 3, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·R Glenn Wells, Brian Marvin
Jul 12, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Quentin BranaMatthieu Bailly
Aug 6, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Raffaele GiubbiniLuca Camoni
Sep 19, 2018·EJNMMI Research·Fayçal Ben BouallègueAlain Manrique
Jul 3, 2018·Current Cardiovascular Imaging Reports·Bryan C RamseyDustin M Thomas
Dec 6, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Navkaranbir S Bajaj, Pradeep Bhambhvani
Jun 2, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Marie A GuerratyPaco E Bravo
May 10, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Wanda AcampaAlberto Cuocolo
Sep 13, 2020·Diagnostics·Muhammad Talha Ayub, Dinesh Kalra
Mar 2, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Gil Kovalski, Tali Sharir
Dec 18, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Pierre-Yves Marie, Alain Manrique
Feb 7, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Jeffrey DoR Glenn Wells
Oct 8, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Wei Fang, Bailing Hsu
Oct 18, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Piotr J SlomkaErnest V Garcia
Nov 1, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Milena J Henzlova, Lane Duvall
Nov 12, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Henry Gewirtz
Jan 4, 2021·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Daniel JuneauRobert A deKemp

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Clinical Trials Mentioned

NCT02278497

Software Mentioned

Corridor 4DM
INVIA
Corridor
Carimas

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