First-wave protease inhibitors for hepatitis C genotype 1 treatment: a real-life experience in Brazilian patients

Revista Da Sociedade Brasileira De Medicina Tropical
Silvana Gama Florencio ChacháAna de Lourdes Candolo Martinelli

Abstract

Licensed for chronic hepatitis C treatment in 2011, the protease inhibitors (PIs) telaprevir (TVR) and boceprevir (BOC), which have high sustained viral responses (SVR), ushered a new era characterized by the development of direct-action drugs against the hepatitis C virus (HCV). The aim of this study was to analyze the effectiveness and safety of BOC and TVR administered with pegylated interferon and ribavirin and to share the experience of a Brazilian reference center. A retrospective descriptive study was conducted in patients with HCV genotype 1 infection who started treatment between July 2013 and December 2015. Data were collected using a computerized system. A total of 115 subjects were included, of which 58 (50.4 %) had liver cirrhosis and 103 (89.6 %) used TVR. The overall SVR rate was 61.7 % (62.1 % for TVR and 58.3 % for BOC). The presence of cirrhosis was associated with a lower SVR rate, whereas patients who relapsed after prior therapy had a greater chance of showing SVR than did non-responders. The incidence of adverse drug reactions (ADRs) was high. Almost all patients (~100 %) presented with hematologic events. Furthermore, treatment had to be discontinued in 15 subjects (13 %) due to severe ADRs. In conclusion...Continue Reading

References

Aug 1, 1973·The British Journal of Surgery·R N PughR Williams
Mar 31, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marc G GhanyUNKNOWN American Association for the Study of Liver Diseases
May 1, 2009·The New England Journal of Medicine·Christophe HézodeUNKNOWN PROVE2 Study Team
Jul 25, 2009·The New England Journal of Medicine·John G McHutchisonUNKNOWN IDEAL Study Team
Apr 9, 2010·The New England Journal of Medicine·John G McHutchisonUNKNOWN PROVE3 Study Team
Jul 17, 2010·Liver International : Official Journal of the International Association for the Study of the Liver·Tarik AsselahPatrick Marcellin
Apr 1, 2011·The New England Journal of Medicine·Fred PoordadUNKNOWN SPRINT-2 Investigators
Apr 1, 2011·The New England Journal of Medicine·Bruce R BaconUNKNOWN HCV RESPOND-2 Investigators
Jun 24, 2011·The New England Journal of Medicine·Ira M JacobsonUNKNOWN ADVANCE Study Team
Jun 24, 2011·The New England Journal of Medicine·Stefan ZeuzemUNKNOWN REALIZE Study Team
Sep 8, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marc G GhanyUNKNOWN American Association for Study of Liver Diseases
Sep 16, 2011·The New England Journal of Medicine·Kenneth E ShermanUNKNOWN ILLUMINATE Study Team
Oct 2, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sandra BeinhardtPeter Ferenci
Oct 16, 2012·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Steven L FlammFred Poordad
Mar 16, 2013·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Rosângela TeixeiraDéborah Crespo
Apr 26, 2015·Journal of Hepatology·UNKNOWN European Association for Study of Liver
May 29, 2015·Arquivos De Gastroenterologia·Paulo R L AlmeidaCristiane Valle Tovo
Aug 21, 2015·World Journal of Gastroenterology : WJG·Javier SalmerónUNKNOWN Alhambra Spanish Study Group
Jul 5, 2016·European Journal of Clinical Investigation·Valentina PecoraroTommaso Trenti
Aug 31, 2016·World Journal of Hepatology· Cleo Study GroupAlfredo Vallone

❮ Previous
Next ❯

Citations

Feb 6, 2020·Cadernos de saúde pública·João Paulo Vilela RodriguesLeonardo Régis Leira Pereira

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.