PMID: 9437561Jan 23, 1998Paper

First week drug concentrations in women with levonorgestrel rod or Norplant capsule implants

Contraception
I SivinJ Stern

Abstract

Forty-two healthy women volunteered to have blood samples drawn at 2, 4, 8, 24, 48, and 168 h (7 days) following placement of levonorgestrel-releasing rod (LNG rod) or of Norplant capsule implants to permit measurement of drug concentrations. Three clinics recruited 10 women each, half of whom used each type of implant. Twelve additional subjects were later enrolled at one site to provide greater detail for the capsule implants. Throughout the week, women with Norplant implants had apparently higher mean drug concentrations than did women with LNG rod implants, but the differences were significant only in the first 48 h after placement (p < 0.05). Maximum levels for capsule implants were found at the 24-h sample (mean, 1358 to 1474 pg/mL) and for the LNG rod implants at 48 h (772 pg/mL). Body weight was negatively correlated with levonorgestrel concentrations at all times (p < 0.05). For several sampling times, differences between clinics in mean concentrations were statistically significant after weight adjustment. Despite differences by implant type, weight, or clinic location, drug concentrations compatible with contraceptive effect were attained within 24 h in users of LNG rod or of Norplant implants, insofar as all women h...Continue Reading

Associated Clinical Trials

Citations

Feb 28, 2002·Contraception·Horacio B Croxatt
Mar 30, 1999·Contraception·J Huber, R Wenzl
Jul 2, 2010·Reproduction, Fertility, and Development·E F HynesMarilyn B Renfree
Mar 27, 2012·Behavioral Ecology and Sociobiology·Annie BissonnetteCarel P van Schaik
Jan 16, 2014·Hand : Official Journal of the American Association for Hand Surgery·Joshua M Adkinson, Jay S Talsania
Dec 10, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kimberly K ScarsiMohammed Lamorde
Sep 23, 2008·Expert Review of Medical Devices·Giuseppe BenagianoManuela Farris
Apr 6, 2019·Nature Biomedical Engineering·Wei LiMark R Prausnitz
Apr 14, 2006·Gan to kagaku ryoho. Cancer & chemotherapy·Shinichiro KameyamaHisataka Uchima
Mar 27, 2018·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Lauren R CirrincioneLaura J Else
Dec 15, 2020·Pharmacology & Therapeutics·Alexis J BickJanet P Hapgood
Oct 13, 2021·Scientific Reports·Eka R GunardiYogi Pasidri

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