First year experience with newly developed Leksell Gamma Knife Perfexion.

Journal of Medical Physics
J P BhatnagarM S Huq

Abstract

A new model of Leksell Gamma Knife(R) (LGK), known as Perfexion (LGK PFX), was introduced by Elekta Instrument, AB, Sweden, in 2006. This model has a radically different design from the earlier models U, B, C and 4C. Dosimetric characteristics of LGK PFX, technical differences between LGK PFX and LGK 4C, experience gained with acceptance testing and commissioning of the LGK PFX, and comparison between LGK PFX and LGK 4C are presented in this study. Excellent agreement is found between the manufacturers recommended values of absorbed dose rate, relative output factors for 4 and 8 mm collimators, coincidence of mechanical and dosimetric isocenter, FWHM for beam profiles for various collimators and those reported in the present study. Excellent agreement is also found between the dosimetric characteristics of LGK PFX and LGK 4C for the 4 and 8 mm collimators. Examples of clinical cases treated with LGK PFX and impact of LGK PFX on workflow and dosimetric conformity of treatment planning is also given. The set up and treatment of patients on the LGK PFX is much more efficient since it is a fully automated system. The system also provides more options to generate plan with high dosimetric conformity.

References

Apr 1, 1990·International Journal of Radiation Oncology, Biology, Physics·A WuW D Bloomer
Dec 1, 1993·International Journal of Radiation Oncology, Biology, Physics·E ShawL Martin
Oct 23, 1998·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·A H Maitz, A Wu
Feb 21, 2002·Neurosurgery·Douglas KondziolkaL Dade Lunsford
Jan 25, 2005·Journal of Neurosurgery·Daniela TlachacovaRoman Liscak
Oct 3, 2007·Neurosurgery·Christer Lindquist, Ian Paddick
Jan 10, 2009·Journal of Neurosurgery·Josef NovotnyL Dade Lunsford

❮ Previous
Next ❯

Citations

May 6, 2016·Medical Physics·Jessica M FagerstromWesley S Culberson
Jan 31, 2017·Medical Physics·Michele ZeverinoRaphaël Moeckli
Jan 16, 2013·Journal of Applied Clinical Medical Physics·Maria Mamalui-HunterRobert E Drzymala
Mar 28, 2012·Expert Review of Neurotherapeutics·Edward A MonacoL Dade Lunsford
Jan 5, 2021·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·A Di RitoJ Thariat
Jul 28, 2021·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·T VeselskyP Osmancikova

❮ Previous
Next ❯

Software Mentioned

Leksell GammaPlan
Film QA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.