Fischer-344 rats are unsuitable for the MCAO filament model due to their cerebrovascular anatomy

Journal of Neuroscience Methods
Michael DittmarFelix Schlachetzki

Abstract

Middle cerebral artery occlusion (MCAO) in Fischer-344 rats results in a small variance of infarct size. However, complications are frequent especially in aged Fisher-344 rats undergoing endovascular suture occlusion of the middle cerebral artery. Analyzing our experiences with 165 Wistar, 13 Sprague-Dawley and 10 F-344 rats, we compared the incidence of impossible thread advancement and subarachnoid hemorrhage, respectively. Magnetic resonance angiography (MRA) was applied to study the course of the internal carotid artery (ICA) in Fischer and Wistar rats. Finally, we performed a structured review of the literature from 1991 to 2005 evaluating reports on Fischer rats subjected to intraluminal filament MCAO. Complications like fruitless filament advancement or subarachnoid hemorrhage were found to be significantly more frequent in Fischer rats than in other strains. MRA revealed significantly more pronounced kinking of the ICA in F-344 than in Wistar rats. In seven publications available on filament MCAO in F-344 rats, complication rates of 50-100% were reported, corroborating our data. Surgical difficulties accompanied by high complication rates due to their cerebrovascular anatomy make Fischer rats unsuitable for filament MCA...Continue Reading

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Citations

Mar 11, 2009·PloS One·Anke PoppChristiane Frahm
May 19, 2010·PloS One·Syamantak MajumderSuvro Chatterjee
Jan 1, 2009·Journal of Experimental Stroke & Translational Medicine·Shimin LiuH Richard Winn
Sep 13, 2014·Translational Stroke Research·Fatima A Sehba
Jul 14, 2011·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Yi-Je ChenHeike Wulff
Jul 19, 2008·Journal of Neuroscience Methods·Athanasios LourbopoulosNikolaos Grigoriadis
May 25, 2007·Pharmacology, Biochemistry, and Behavior·Aysan Durukan, Turgut Tatlisumak
Jan 30, 2010·Journal of Neuroscience Methods·Amir LivnatAvraham Mayevsky
Nov 7, 2012·Journal of the American Heart Association·Christopher C LayRon D Frostig
Feb 11, 2016·Translational Stroke Research·Kyra J Becker
Oct 10, 2018·Frontiers in Pharmacology·Eram FauziaSyed Shadab Raza
Jul 26, 2019·Scientific Reports·Jungbin SongHocheol Kim

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