Fisetin exerts antihyperalgesic effect in a mouse model of neuropathic pain: engagement of spinal serotonergic system

Scientific Reports
Xin ZhaoWen-Hua Zhou

Abstract

Fisetin, a natural flavonoid, has been shown in our previous studies to exert antidepressant-like effect. As antidepressant drugs are clinically used to treat chronic neuropathic pain, this work aimed to investigate the potential antinociceptive efficacies of fisetin against neuropathic pain and explore mechanism(s). We subjected mice to chronic constriction injury (CCI) by loosely ligating the sciatic nerves, and Hargreaves test or von Frey test was used to assess thermal hyperalgesia or mechanical allodynia, respectively. Chronic fisetin treatment (5, 15 or 45 mg/kg, p.o.) ameliorated thermal hyperalgesia (but not mechanical allodynia) in CCI mice, concomitant with escalated levels of spinal monoamines and suppressed monoamine oxidase (MAO)-A activity. The antihyperalgesic action of fisetin was abolished by chemical depletion of spinal serotonin (5-HT) but potentiated by co-treatment with 5-HTP, a precursor of 5-HT. Moreover, intraperitoneal (i.p.) or intrathecal (i.t.) co-treatment with 5-HT7 receptor antagonist SB-258719 completely abrogated fisetin's antihyperalgesia. These findings confirm that chronic fisetin treatment exerts antinociceptive effect on thermal hyperalgesia in neuropathic mice, with spinal serotonergic sys...Continue Reading

References

Oct 17, 1980·European Journal of Pharmacology·J L Hylden, G L Wilcox
Jan 6, 1999·Archives of Pharmacal Research·H CheongK M Kim
Jul 20, 2001·British Journal of Anaesthesia·D BridgesA S Rice
May 30, 2002·Progress in Neurobiology·Mark J Millan
Jun 11, 2002·Annual Review of Nutrition·Julie A Ross, Christine M Kasum
Mar 1, 1957·British Journal of Pharmacology and Chemotherapy·T J HALEY, W G MCCORMICK
Jan 18, 2005·Pharmacology, Biochemistry, and Behavior·Tom DowdallTheo F Meert
Aug 24, 2005·Anesthesia and Analgesia·Takahiro SuzukiTakashi Mashimo
Jun 10, 2006·Trends in Pharmacological Sciences·Juan A MicóAlain Eschalier
Nov 17, 2009·British Journal of Pharmacology·Nada Choucair-JaafarMichel Barrot
Sep 17, 2010·The American Journal of Psychiatry·Vaishnav Krishnan, Eric J Nestler
Feb 15, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Nagaiya RavichandranGanesan Vijaiyan Siva
Sep 6, 2011·Biological Psychiatry·Ipek YalcinMichel Barrot
Dec 27, 2011·Behavioural Brain Research·Linlin ZhenJianchun Pan
Feb 20, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jardel Gomes VillarinhoJuliano Ferreira
Jan 1, 2012·Journal of Parkinson's Disease·Mital Y PatelKenza E Benzeroual

❮ Previous
Next ❯

Citations

Sep 28, 2016·BioMed Research International·Azucena I Carballo-VillalobosFrancisco J López-Muñoz
May 17, 2018·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Ajeet Kumar SinghManjula Vinayak
Mar 11, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Paramita Basu, Arpita Basu
Sep 28, 2020·Neuroscience and Biobehavioral Reviews·Ana Margarida CunhaHugo Leite-Almeida

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.