Abstract
Lung cancer is the most prevalent malignant tumor type in the developed world and the discovery of novel anti-tumor drugs is a research hotspot. Fisetin, a naturally occurring flavonoid, has been reported to have anti-cancer effects in multiple tumor types. The present study found that fisetin inhibited the growth and migration of non-small cell lung cancerin vitro. MTT, wound-healing, cell-matrix adhesion and Transwell assays were performed and demonstrated that fisetin suppressed proliferation, migration, adhesion and invasion, respectively. Flow cytometric analysis indicated that fisetin induced apoptosis in the A549 cell line by decreasing the expression of c-myc, cyclin-D1, cyclooxygenase-2, B cell lymphoma-2, CXC chemokine receptor type 4, cluster of differentiation 44 and metalloproteinase-2/9, increasing the expression of cyclin dependent kinase inhibitor (CDKN) 1A/B, CDKN2D and E-cadherin and increasing the activity of caspase-3/9 via targeting the extracellular signal-regulated kinase signaling pathway. The results provided comprehensive evidence for the anti-tumor effects of fisetin in non-small cell lung cancerin vitro, which may provide a novel approach for clinical treatment.
References
Jan 31, 1997·The Journal of Biological Chemistry·H Ellinger-ZiegelbauerU Siebenlist
Nov 2, 1999·Biochemical and Biophysical Research Communications·Y Ishikawa, M Kitamura
Aug 26, 2000·The Journal of Nutrition·Y AraiN Kinae
Feb 14, 2002·Biochemical Pharmacology·Woan Rouh LeeYen Chou Chen
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Jul 11, 2002·Archives of Toxicology·Yen-Chou ChenLing-Ling Yang
Jun 29, 2004·Life Sciences·Ya-Ling HsuChun-Ching Lin
Feb 4, 2005·Journal of Medicinal Chemistry·Heshu LuUrsula Schulze-Gahmen
Nov 30, 2005·Prostate Cancer and Prostatic Diseases·A Q HaddadL H Klotz
Aug 1, 2006·Oncogene·R LinT S Edgington
Oct 20, 2006·Proceedings of the National Academy of Sciences of the United States of America·Pamela MaherKazuho Abe
Mar 25, 2008·Carcinogenesis·Naghma KhanHasan Mukhtar
Oct 17, 2008·Cancer Research·Naghma KhanHasan Mukhtar
Nov 28, 2008·Carcinogenesis·Yewseok SuhHasan Mukhtar
Aug 12, 2009·International Journal of Cancer. Journal International Du Cancer·Imtiyaz MurtazaHasan Mukhtar
Sep 4, 2009·Journal of Agricultural and Food Chemistry·Yi-Chen LiaoTai-An Chiang
Jun 10, 2010·Carcinogenesis·Yewseok SuhHasan Mukhtar
Aug 3, 2010·Cancer Letters·Songgang LiYingbin Liu
Jan 14, 2012·Immunopharmacology and Immunotoxicology·Sun-Chae KimSung-Hoon Kim
Feb 1, 2012·European Journal of Pharmacology·Fera Y GohW S Fred Wong
Jun 27, 2013·Experimental Dermatology·Harish C PalFarrukh Afaq
Jul 19, 2013·PloS One·Laurent LéotoingVéronique Coxam
Aug 14, 2013·PloS One·Ruey-Hwang ChouYi-Hsien Hsieh
Jan 28, 2014·PloS One·Harish Chandra PalFarrukh Afaq
Sep 16, 2014·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayFreddie Bray
Feb 3, 2015·Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia·Keishi KawasakiYukihiro Yoshida
Jan 12, 2016·Therapeutic Advances in Medical Oncology·Ivana Sullivan, David Planchard
Jan 28, 2016·BMC Medical Informatics and Decision Making·Manuel LuqueCarlos Disdier
Citations
Sep 5, 2019·International Journal of Molecular Sciences·Oana ZanoagaIoana Berindan-Neagoe
Oct 18, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mai KhaterHelen M I Osborn
May 11, 2021·Cancer Biology & Therapy·Xiao-Lin WangLing-Feng Min
Jun 5, 2021·Journal of Cell Communication and Signaling·Arun J Singh, Joe W Gray