PMID: 3765347Jun 1, 1986Paper

Fish and antibiotics: pharmacokinetics of sulphadimidine in carp (Cyprinus carpio)

Veterinary Immunology and Immunopathology
J L GrondelO L Haenen

Abstract

Pharmacokinetics, metabolism and clearance of sulphadimidine (SDM) were studied after a single intraperitoneal injection of SDM in carp at 20 degrees C. SDM was acetylated and hydroxylated to a small extent. The main metabolite was N4-acetyl derivative amounting only 2% of the total drug dose excreted; hydroxylation was less important (0.41% of the dose). The elimination half-life for SDM in carp was 17.5 h. The clearance values for SDM and its metabolites were equivalent. The importance of pharmacokinetic studies in different fish species is discussed.

Citations

Nov 1, 1995·Veterinary Immunology and Immunopathology·B MagnadóttirB K Gudmundsdóttir
Jun 1, 1993·Journal of Veterinary Pharmacology and Therapeutics·F K AlaviC R Clarke

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