Fish and marine fatty acids intakes, the FADS genotypes and long-term weight gain: a prospective cohort study

BMJ Open
Tao HuangLu Qi

Abstract

We tested whether genetic variants near fatty acid desaturases gene (FADS) cluster, which were recently identified to be signatures of adaptation to fish-rich and n-3 polyunsaturated fatty acids (PUFAs)-rich diet, interacted with these dietary factors on change in body mass index (BMI). Three FADS variants were examined for gene-diet interactions on long-term (~10 years) changes in BMI and body weight in four prospective cohort studies. Population based study. 11 323 women from the Nurses' Health Study (NHS), 6833 men from the Health Professionals Follow-up Study (HPFS) and replicated in 6254 women from the Women's Health Initiative (WHI) and 5 264 Chinese from the Singapore Chinese Health Study (SCHS). Long-term (~10 years) changes in BMI and body weight. In the NHS and HPFS cohorts, food-sourced n-3 PUFAs intake showed interactions with the FADS rs174570 on changes of BMI (P for interaction=0.02 in NHS, 0.05 in HPFS and 0.007 in combined). Such interactions were replicated in two independent cohorts WHI and SCHS (P for interaction=0.04 in WHI, 0.02 in SCHS and 0.001 in combined). The genetic associations of the FADS rs174570 with changes in BMI increased across the tertiles of n-3 PUFAs in all the cohorts. Fish intake also ac...Continue Reading

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Citations

Apr 17, 2021·Current Opinion in Clinical Nutrition and Metabolic Care·Omar Ramos-LopezUNKNOWN Collaborators: Rodrigo San-Cristobal and Maria P. Portillo

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Methods Mentioned

BETA
genotyping
Chip

Software Mentioned

SAS

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