PMID: 15378837Sep 24, 2004Paper

FISH chromosome aberration analysis on retired radiation workers from the Sellafield nuclear facility

Radiation Research
E Janet TawnRobert E Tarone

Abstract

Chromosome analysis using fluorescence in situ hybridization was undertaken on 294 retired workers from the British Nuclear Fuels plc facility at Sellafield, 95 with external occupational exposure <50 mSv, 108 with 50-499 mSv, and 91 with >500 mSv. In univariate analyses, external dose (P <10-s) and age (P = 0.0075) were significantly associated with translocation frequency, but no effect was found for smoking status. In a multivariate analysis with age and external dose as continuous variables, the slopes were 0.017 +/- 0.0075 x 10(-2) translocations per cell per year for age (P = 0.024) and 1.11+/- 0.190 x 10(-2) translocations per cell per sievert for external dose (P < 10(-5)). The dose response for translocation induction for occupational workers is similar to the linear component of in vitro dose-response curves, thus supporting the use of translocation frequency for retrospective biological dosimetry in situations of chronic low-dose exposure occurring over many years. The dose response obtained in this study is lower than the linear component of the dose response for stable chromosome aberrations obtained for the Japanese atomic bomb survivors. Thus, if chromosome aberration levels are indicative of cancer risk, this wo...Continue Reading

References

Jul 1, 1992·International Journal of Radiation Biology·J N LucasJ Gray
Feb 1, 1997·International Journal of Radiation Biology·G SnigiryovaM Bauchinger
Jan 1, 1997·Radiation Oncology Investigations·E J Tawn
Aug 5, 1998·International Journal of Radiation Biology·M BauchingerA Akleyev
Apr 11, 2000·International Journal of Radiation Biology·E J TawnR E Tarone
Aug 10, 2000·Radiation Research·D A Pierce, D L Preston
Feb 22, 2001·Radiation Research·D J BrennerR K Sachs
May 16, 2001·Radiation Research·C Mothersill, C Seymour
Dec 14, 2001·Radiation Research·K GeorgeF A Cucinotta
Mar 22, 2002·Mutation Research·Stefano Bonassi, William W Au
Aug 27, 2002·Radiation Protection Dosimetry·K M PriseB D Michael
Oct 30, 2003·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·E Janet Tawn, Caroline A Whitehouse
Jan 31, 2004·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·E Janet Tawn, Caroline A Whitehouse

❮ Previous
Next ❯

Citations

Mar 29, 2013·Journal of Radiation Research·Rositsa HristovaDonka Benova
May 26, 2007·Radiation Research·Parveen BhattiAlice J Sigurdson
Jul 25, 2013·International Journal of Molecular Sciences·Aaron RobertsonAlison Curnow
Jul 6, 2010·Radiation and Environmental Biophysics·Parveen BhattiAlice J Sigurdson
Mar 31, 2005·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·E Janet Tawn, Caroline A Whitehouse
Mar 31, 2005·Radiation Protection Dosimetry·H ThierensI Boesman
Mar 1, 2008·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·Kevin K CadwellE Janet Tawn
Sep 15, 2005·Nuclear Medicine Communications·Françoise Guiraud-VitauxNicole Colas-Linhart
Jan 1, 2015·Health Physics·André BouvilleCary Zeitlin
Jun 2, 2005·Radiation Protection Dosimetry·A A EdwardsP Voisin
Jan 27, 2006·Radiation Research·Craig S WildingDouglass M Turnbull
Dec 9, 2014·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·E Janet TawnPatricia Jonas
May 4, 2006·Radiation Research·E Janet TawnAnthony E Riddell
Aug 1, 2008·Radiation Research·Parveen BhattiAlice J Sigurdson
Sep 30, 2005·Mutation Research·Radim J SramPetra Musilova

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.