Fish oil ameliorates renal injury and hyperlipidemia in the Milan normotensive rat model of focal glomerulosclerosis.

Journal of the American Society of Nephrology : JASN
D J GoldsteinD J Salant

Abstract

Rats of the Milan normotensive rat strain (MNS) spontaneously develop severe proteinuria and excessive glomerular thromboxane (Tx)A2 production at a young age. These abnormalities are accompanied by podocyte alterations, progressive focal glomerulosclerosis (FGS), and interstitial fibrosis, resembling human FGS. Since it has been shown that pharmacologic Tx-synthase inhibition protects MNS rats from these changes, it was hypothesized that a fish oil (FO) enriched diet, by enhancing TxA3 production instead of TxA2, might afford similar protection, compared with diets enriched in safflower oil (SO) or lard (LD). Rats were pair-fed 11% fat diets from age of 1 to 11 months. Glomerular TxA2 at 11 months was significantly lower in PO-fed rats than in SO- and LD-fed rats (11 +/- 3.0, 69 +/- 3.0, 59 +/- 19.0 nanograms per min/mg, respectively; P < 0.001). At 3 months, urinary albumin excretion was similar among the groups. Over the course of the study, rats fed FO developed significantly less albuminuria than the SO and LD groups (P < 0.001 by analysis of variance for repeated measures), such that the values at 11 months were 25 +/- 5.8, 49 +/- 8.7, and 68 +/- 13.0 mg/24h, respectively. Serum cholesterol and triglycerides were also sig...Continue Reading

Citations

Apr 30, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Nancy G KutnerXavier Aviles
Mar 11, 2000·The Journal of Laboratory and Clinical Medicine·S A BrownD R Finco
Dec 1, 1996·Kidney International·D J GoldsteinD J Salant
Nov 26, 2009·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Shubha PriyamvadaA N K Yusufi
Sep 17, 2010·American Journal of Physiology. Renal Physiology·Sekiko TanedaHideaki Oda

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