Fish Oil and Primrose Oil Suppress the Progression of Alzheimer's Like Disease Induced by Aluminum in Rats

Journal of Oleo Science
Sahar Y Al-OkbiNaglaa A Ali

Abstract

The role of fish oil, primrose oil and their mixture in ameliorating the changes in Alzheimer's like model was evaluated in rats. Primrose oil and primrose/fish oil mixture fatty acids composition was assessed by gas chromatography. The rat experiment consisted of 5 groups; the first fed on balanced diet as control normal (CN); the other four groups treated with intraperitoneal aluminum lactate and consumed dyslipidemic diet; one group served as control Alzheimer's like disease (CA) while the other three groups (test groups) received daily oral dose from primrose oil, fish oil and primrose/fish oil mixture separately for 5 weeks. Results showed primrose oil and primrose/ fish oil mixture to contain gamma linolenic acid as 9.15 and 4.3% of total fatty acids, respectively. Eicosapentaenoic and docosahexaenoic were present as 10.9 and 6.5 %, respectively in the oil mixture. Dyslipidemia and increased erythrocyte sedimentation rate (ESR), plasma butyrylcholinesterase (BChE), brain malondialdehyde (MDA) and NO with decrease in plasma magnesium, brain catalase, reduced glutathione, body weight gain and brain weight were demonstrated in CA compared to CN. Brain histopathology and immuno-histochemistry showed neuronal degeneration and ...Continue Reading

References

Nov 15, 1978·Clinica Chimica Acta; International Journal of Clinical Chemistry·K Satoh
Mar 1, 1990·Journal of Neurochemistry·K GulyaP Kása
Jan 1, 1984·Methods in Enzymology·H Aebi
Jul 17, 2004·Journal of Neurochemistry·Pattie S GreenJay W Heinecke
Mar 25, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Giselle P LimGreg M Cole
Nov 26, 2005·Journal of Alzheimer's Disease : JAD·Masahiro Kawahara
Feb 9, 2008·The American Journal of Clinical Nutrition·Floyd H ChiltonMichael C Seeds
Jan 30, 2010·Cell Biology and Toxicology·Alessandro CastorinaVelia D'Agata
Feb 16, 2010·Neuron·Inna SlutskyGuosong Liu
Apr 14, 2010·Archives of Neurology·Yian GuNikolaos Scarmeas
Nov 4, 2010·JAMA : the Journal of the American Medical Association·Joseph F QuinnPaul S Aisen
Feb 15, 2012·Advances in Nutrition·Danielle SwansonShaker A Mousa
Jun 3, 2014·Lipids in Health and Disease·Hitoshi MaruyamaOsamu Yokosuka
Oct 28, 2014·CNS & Neurological Disorders Drug Targets·Gohar MushtaqMohammad A Kamal
Oct 24, 2015·Brain Pathology·Ramesh KandimallaKiran Dip Gill
Feb 14, 2017·Environmental Toxicology and Pharmacology·Olayemi Joseph OlajideKehinde Yomi Ogunrinola
Jun 19, 2018·Molecular Neurobiology·S VelaMaría J Ramirez
Aug 8, 2018·Current Clinical Pharmacology·Thekkuttuparambil Ananthanarayanan Ajith
Aug 17, 2018·Antioxidants·Magdalena TimoszukElżbieta Skrzydlewska
Oct 20, 2018·Journal of Ayurveda and Integrative Medicine·Deepthi RapakaAnnapurna Akula

❮ Previous
Next ❯

Citations

Aug 31, 2021·Journal of Nutritional Science·Kazunari KadokuraKohei Suruga

❮ Previous
Next ❯

Related Concepts

Related Feeds

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.