Fish oil and vascular endothelial protection: bench to bedside

Free Radical Biology & Medicine
Pitchai Balakumar, Gaurav Taneja

Abstract

Fish oil is recommended for the management of hypertriglyceridemia and to prevent secondary cardiovascular disorders. Fish oil is a major source of ω-3-polyunsaturated fatty acids (PUFAs) such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Clinical studies suggest that fish oil not only prevents the incidence of detrimental cardiovascular events, but also lowers the cardiovascular mortality rate. In addition to a classic lipid-lowering action, ω-3-PUFAs in fish oil could regulate blood pressure and enhance vascular integrity and compliance. Additionally, ω-3-PUFAs have the ability to protect vascular endothelial cells by decreasing oxidative stress, halting atherosclerotic events, and preventing vascular inflammatory and adhesion cascades. Intriguingly, recent studies have demonstrated that ω-3-PUFAs improve the function of vascular endothelium by enhancing the generation and bioavailability of endothelium-derived relaxing factor (nitric oxide) through upregulation and activation of endothelial nitric oxide synthase (eNOS). This certainly opens up a new area of research identifying potential mechanisms influencing fish oil-mediated functional regulatory action on vascular endothelium. We address in this review t...Continue Reading

References

Jun 1, 1991·Mayo Clinic Proceedings·D D Wagner, R Bonfanti
Jan 1, 1989·Journal of Cardiovascular Pharmacology·H KuriharaT Masaki
Jun 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·E J CoreyJ R Cashman
Oct 1, 1994·Clinical and Experimental Pharmacology & Physiology·J P Chin, A M Dart
Nov 1, 1996·Progress in Cardiovascular Diseases·E Bassenge
Mar 12, 1999·Journal of Molecular and Cellular Cardiology·J V Mombouli, P M Vanhoutte
Feb 26, 2000·Cardiovascular Research·P J Andrew, B Mayer
Feb 26, 2000·Cardiovascular Research·I Fleming, R Busse
Nov 8, 2001·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·P Poredos
Sep 12, 2002·Pharmacological Reviews·Babak RazaniMichael P Lisanti
Nov 20, 2002·Circulation·Penny M Kris-EthertonUNKNOWN American Heart Association. Nutrition Committee
Apr 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·Steven P JonesDavid J Lefer
Oct 17, 2003·Current Drug Targets. Inflammation and Allergy·Guofeng RenNikolaos G Frangogiannis
Oct 22, 2003·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Keigo ChisakiToshiaki Nakajima
Apr 3, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Diego LópezM Teresa Mitjavila
Jun 17, 2004·Circulation·Jean Davignon, Peter Ganz
Jul 16, 2004·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Hasan ErdoganOzge Ardicoglu
Feb 22, 2005·Molecular Aspects of Medicine·Khalid M Naseem
Jun 18, 2005·Memórias do Instituto Oswaldo Cruz·William C Sessa
Nov 1, 2005·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·James W E RushDrew A Graham
Jul 15, 2006·Journal of Molecular and Cellular Cardiology·Peter F MountDavid A Power
Dec 16, 2006·Basic & Clinical Pharmacology & Toxicology·Pitchai Balakumar, Manjeet Singh

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Citations

Feb 23, 2013·Current Hypertension Reports·Arrigo F G Cicero, Claudio Borghi
Feb 13, 2014·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Kazuo YamagataMotoki Tagami
Dec 23, 2014·Marine Drugs·Ilse A C Arnoldussen, Amanda J Kiliaan
Sep 13, 2015·Annals of Medicine·Cesare R SirtoriArrigo F G Cicero
Nov 12, 2015·Journal of Food Science·Natalie Marinho DantasTatiana Saldanha
Dec 24, 2015·Frontiers in Cardiovascular Medicine·Bibhuti Bhusan KakotiSiva Kumar Panguluri
Sep 28, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Pitchai BalakumarSuresh Nanditha
Mar 20, 2015·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Arrigo F G Cicero, Alessandro Colletti
Mar 23, 2013·Blood·Simeon Pollack
Oct 27, 2014·Lipids·Maria das Graças Coelho de SouzaEliete Bouskela
Jun 12, 2014·International Journal of Molecular Sciences·Che-Hsin LeeYu-Jung Cheng
May 24, 2013·International Journal of Molecular Sciences·Isabella SaviniLuciana Avigliano
Apr 24, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Oliver M ShannonMario Siervo
May 19, 2018·Circulation·Eric B RimmUNKNOWN American Heart Association Nutrition Committee of the Council on Lifestyle and Cardiometabolic Health; Council on Epidemiolo
Dec 21, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Kalliopi KaratziSebastien Czernichow
May 1, 2019·International Journal of Molecular Sciences·Matilde AmatrudaElvira Verduci
Aug 22, 2017·Frontiers in Endocrinology·Undurti N Das
Apr 28, 2019·Animals : an Open Access Journal From MDPI·Laurentiu Mihai PaladeIonelia Taranu
Jan 8, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Roberta CazzolaBenvenuto Cestaro
Sep 25, 2020·Rheumatology Advances in Practice·Julia C KuszewskiPeter R C Howe
Feb 23, 2020·Photodiagnosis and Photodynamic Therapy·Maria Camila Pruper de FreitasNágila Raquel Teixeira Damasceno

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