Fish oil decreases hepatic lipogenic genes in rats fasted and refed on a high fructose diet

Nutrients
Gabriela S de CastroHelio Vannucchi

Abstract

Fasting and then refeeding on a high-carbohydrate diet increases serum and hepatic triacylglycerol (TAG) concentrations compared to standard diets. Fructose is a lipogenic monosaccharide which stimulates de novo fatty acid synthesis. Omega-3 (n-3) fatty acids stimulate hepatic β-oxidation, partitioning fatty acids away from TAG synthesis. This study investigated whether dietary n-3 fatty acids from fish oil (FO) improve the hepatic lipid metabolic response seen in rats fasted and then refed on a high-fructose diet. During the post-prandial (fed) period, rats fed a FO rich diet showed an increase in hepatic peroxisome proliferator-activated receptor α (PPAR-α) gene expression and decreased expression of carbohydrate responsive element binding protein (ChREBP), fatty acid synthase (FAS) and microsomal triglyceride transfer protein (MTTP). Feeding a FO rich diet for 7 days prior to 48 h of fasting resulted in lower hepatic TAG, lower PPAR-α expression and maintenance of hepatic n-3 fatty acid content. Refeeding on a high fructose diet promoted an increase in hepatic and serum TAG and in hepatic PPAR-α, ChREBP and MTTP expression. FO did not prevent the increase in serum and hepatic TAG after fructose refeeding, but did decrease he...Continue Reading

References

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Citations

May 13, 2017·Clinical and Molecular Hepatology·Stephen Caldwell
Sep 13, 2017·International Journal of Obesity : Journal of the International Association for the Study of Obesity·L M LaiglesiaM J Moreno-Aliaga
Sep 24, 2020·Phytotherapy Research : PTR·Meysam ZarezadehMehrangiz Ebrahimi Mamaghani
Apr 24, 2018·International Journal of Pediatrics·Christoph BaumannReiner Buchhorn

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Methods Mentioned

BETA
enzyme-linked
ELISA
PCR

Software Mentioned

GraphPad
GraphPad Prism

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