Fish oil dietary supplementation reduces Ia expression in rat and mouse peritoneal macrophages

Clinical Immunology and Immunopathology
J MosqueraG Parra

Abstract

Preliminary studies suggest that administration of fish oil fatty acids may be beneficial in several immunological diseases; therefore, we studied the effect of fish oil dietary supplementation on the expression of Ia in stimulated murine peritoneal macrophages. Rats (n = 19) and mice (n = 27) on standard rodent feeding were separated in experimental (E) and control (C) groups that received fish oil or saline solution, respectively, daily for 4 weeks by esophageal gavage. Cholesterol serum levels were significantly lowered by fish oil (E vs C, P less than 0.01). E and C groups were injected intraperitoneally with Listeria monocytogenes (LM) and peritoneal cells were harvested 4 and 7 days after infection. Decreased expression of Ia induced by LM was found in rats (C = 49.68 +/- 5.09%, E = 16.95 +/- 4.3%, P less than 0.01) and mice (C = 47.38 +/- 7.63%, E = 26.66 +/- 1.92%, P less than 0.01). Animals with a more pronounced depression of serum cholesterol (reduction of 44.04 +/- 1.52% of baseline levels) had more depression of Ia expression (6.47 +/- 1.22%, P less than 0.001 vs control). Reduction of Ia expression was not related to PGE2 production by peritoneal cells. Reduction of Ia expression by fish oil could induce down-regu...Continue Reading

References

Feb 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·P NeedlemanH Sprecher
Aug 1, 1985·The Journal of Clinical Investigation·C S TrippP Needleman
Oct 1, 1985·The Journal of Experimental Medicine·C A LeslieE S Cathcart
Jan 1, 1984·Annual Review of Immunology·E R Unanue
Sep 9, 1982·Nature·D S SnyderE R Unanue
Jun 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·E J CoreyJ R Cashman
Feb 1, 1984·European Journal of Immunology·D I Beller
Apr 1, 1982·The Journal of Experimental Medicine·W A ScottZ A Cohn
Dec 1, 1980·The Journal of Experimental Medicine·M G ScherE R Unanue

❮ Previous
Next ❯

Citations

Mar 30, 1999·The Proceedings of the Nutrition Society·D A Hughes
Jul 10, 1998·The Proceedings of the Nutrition Society·E A Miles, P C Calder
Feb 27, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·C FengK L Fritsche
May 24, 2013·Nutrients·Lisa M HarrisonUma S Babu
Sep 3, 2002·Clinical and Diagnostic Laboratory Immunology·Manuel A de PabloGerardo Alvarez de Cienfuegos
Jan 5, 2000·The American Journal of Clinical Nutrition·D A Hughes, A C Pinder
Mar 3, 1998·Nutrition Reviews·P C Calder
May 1, 1997·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·K L FritscheJ N Berg
Jan 1, 1997·Advances in Enzyme Regulation·P C Calder
Feb 17, 2001·The Journal of Nutritional Biochemistry·J E. Teitelbaum, W Allan Walker

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.