Fisher scientific award lecture - the capsular polysaccharides of Group B Streptococcus and Streptococcus suis differently modulate bacterial interactions with dendritic cells

Canadian Journal of Microbiology
Mariela Segura

Abstract

Infections with encapsulated bacteria cause serious clinical problems. Besides being poorly immunogenic, the bacterial capsular polysaccharide (CPS) cloaks antigenic proteins, allowing bacterial evasion of the host immune system. Despite the clinical significance of bacterial CPS and its suggested role in the pathogenesis of the infection, the mechanisms underlying innate and, critically, adaptive immune responses to encapsulated bacteria have not been fully elucidated. As such, we became interested in studying the CPS of two similar, but unique, streptococcal species: Group B Streptococcus (GBS) and Streptococcus suis . Both streptococci are well encapsulated, some capsular types are more virulent than others, and they can cause severe meningitis and septicemia. For both pathogens, the CPS is considered the major virulence factor. Finally, these two streptococci are the sole Gram-positive bacteria possessing sialic acid in their capsules. GBS type III is a leading cause of neonatal invasive infections. Streptococcus suis type 2 is an important swine and emerging zoonotic pathogen in humans. We recently characterized the S. suis type 2 CPS. It shares common structural elements with GBS, but sialic acid is α2,6-linked to galacto...Continue Reading

References

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Aug 24, 2004·Infection and Immunity·Mariela SeguraMartin Olivier

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Citations

Jan 22, 2013·Applied and Environmental Microbiology·Jamila Anba-MondoloniMarie-Christine Champomier-Vergès
Jun 25, 2014·Future Microbiology·Mariela SeguraMarcelo Gottschalk
Apr 27, 2016·Infection and Immunity·Guillaume Goyette-DesjardinsMariela Segura
Jul 15, 2017·Frontiers in Microbiology·Paul LemireMariela Segura

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