Jul 1, 1977

Fisher's syndrome: a pharmacological study of the pupils

Annals of Neurology
T OkajimaH Tokuomi

Abstract

A pharmacological study was performed in the involved pupils to demonstrate the site of lesion in a patient with Fisher's syndrome who showed marked ptosis, complete external ophthalmoplegia, pupillary involvement with anisocoria, facial paresis, ataxia, areflexia, and albuminocytological dissociation in the cerebrospinal fluid. The instillation of 2.5% methacholine produced mild constriction of one pupil. This response was not detectable in the recovery stage. The instillation of 1.25% l-epinephrine produced marked bilateral dilation of the pupils, in both the early and recovery stages. Instillation of 5% tyramine produced pupillary dilation as in the normal pupil. The response to 5% cocaine, tested only in the recovery stage, was weak in one pupil. These results imply that the pupillary involvement was due to peripheral involvement of the sympathetic and parasympathetic nervous systems. The lesion in the sympathetic nervous system was preganglionic, but in the parasympathetic nervous system the precise localization could not be determined.

Mentioned in this Paper

Establishment and Maintenance of Localization
Ophthalmoplegia
Entire Parasympathetic Nervous System
Ataxia as Late Effect of Cerebrovascular Disease
Sympathetic Nervous System
Miller Fisher Syndrome
Ptosis
Pupillary Dilation Function
Pathological Dilatation
Cerebrospinal Fluid

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