Fishing for intestinal cancer models: unraveling gastrointestinal homeostasis and tumorigenesis in zebrafish

Zebrafish
Ana FaroHans Clevers

Abstract

Zebrafish has proven to be a highly versatile model for comprehensive studies of gene function in development. Given that the molecular pathways involved in epithelial carcinogenesis appear to be conserved across vertebrates, zebrafish is now considered as a valid model to study tumor biology. Development and homeostasis in multicellular organisms are dependent on a complex interplay between cell proliferation, migration, differentiation, and cell death. The Wnt signaling pathway is a major signaling pathway during embryonic development and is the key regulator of self-renewal homeostasis in several adult tissues. A large body of knowledge on adult stem-cell biology has arisen from the study of the intestinal epithelium over the past 20 years. The Wnt pathway has appeared as its principal regulator of homeostatic self-renewal. Moreover, most cancers of the intestine are caused by activating mutations in the Wnt pathway. Recently, zebrafish models have been developed to study Wnt pathway-induced cancer. An appealing avenue for cancer research in zebrafish is large-scale screens to identify chemotherapeutic and chemopreventive agents in conjunction with the in vivo imaging approaches that zebrafish affords.

References

Aug 9, 1991·Science·K W KinzlerD McKechnie
Dec 1, 1991·British Journal of Cancer·C M BartonR C Williamson
Jan 1, 1990·International Journal of Radiation Biology·C S PottenS A Roberts
Mar 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·B BressacM Ozturk
Jun 1, 1990·Cell·E R Fearon, B Vogelstein
Jun 1, 1990·The Anatomical Record·R Calvert, P Pothier
Mar 1, 1989·The Journal of Pathology·F M van den BergJ M Walboomers
Jun 11, 1987·The New England Journal of Medicine·F M GiardielloG D Luk
May 1, 1974·Cell and Tissue Kinetics·C S PottenE Hamilton
May 9, 1995·Proceedings of the National Academy of Sciences of the United States of America·M OshimaM Taketo
Jan 1, 1994·Current Biology : CB·T JacksR A Weinberg
Sep 13, 1994·Proceedings of the National Academy of Sciences of the United States of America·R FoddeP M Khan
Jan 1, 1993·Human Mutation·H Nagase, Y Nakamura
Dec 10, 1993·Science·B RubinfeldP Polakis
Oct 18, 1996·Cell·K W Kinzler, B Vogelstein
Aug 1, 1997·Nature Genetics·D J MarshC Eng
Jan 15, 1998·Nature·A HemminkiL A Aaltonen
Aug 11, 1998·Nature Genetics·A Di CristofanoP P Pandolfi
Sep 4, 1998·Science·T C HeK W Kinzler
Nov 13, 1998·Proceedings of the National Academy of Sciences of the United States of America·M P MyersN K Tonks
Nov 13, 1998·Proceedings of the National Academy of Sciences of the United States of America·P DuesbergR Hehlmann
Dec 31, 1998·Gastroenterology·M Bjerknes, H Cheng

❮ Previous
Next ❯

Citations

Oct 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Sarah E CheesmanKaren Guillemin
Jun 15, 2011·Developmental Biology·David J ForsthoefelPhillip A Newmark
Sep 1, 2016·Development·Narges AghaallaeiJoachim Wittbrodt
Jan 31, 2019·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Jianlong LiKenneth N Wallace
Jan 15, 2014·Experimental Biology and Medicine·Joshua K RobertsonTerence J Van Raay
Dec 2, 2020·Annual Review of Animal Biosciences·Nuno BorgesRodrigo Costa
Apr 11, 2013·Development·Shigeo TakashimaVolker Hartenstein

❮ Previous
Next ❯

Methods Mentioned

BETA
ubiquitination
transgenic
imaging techniques
chemical treatments

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.