PMID: 9461438Mar 7, 1998

Fission yeast Slp1: an effector of the Mad2-dependent spindle checkpoint

S H KimTomohiro Matsumoto


Mad2 is a component of the spindle checkpoint, which delays the onset of anaphase until all chromosomes are attached to the spindle. Mad2 formed a complex with Slp1, a WD (tryptophan-aspartic acid)-repeat protein essential for the onset of anaphase. When the physical interaction between the two proteins was disrupted, the spindle checkpoint was no longer functional. Post-anaphase events such as chromosome decondensation and the next round of DNA replication were not delayed even when the spindle assembly was incomplete. This relief of dependence appears to be a result of deregulation of ubiquitin-dependent proteolysis mediated by the anaphase-promoting complex.


Jul 13, 2000·Cell Motility and the Cytoskeleton·M S CampbellG J Gorbsky
Nov 26, 2002·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·John J TysonBéla Novák
May 13, 2006·Current Genetics·Szu Shien NgChristopher J McInerny
Feb 18, 2010·Chromosoma·Frederick G WesthorpeStephen S Taylor
Jun 18, 2003·Biochemical and Biophysical Research Communications·Naihan XuDonald C Chang
Oct 22, 2003·Archives of Medical Research·Carla Lopes, Claudio E Sunkel
Jan 23, 1999·Current Opinion in Cell Biology·J M Peters
Dec 22, 1999·Current Opinion in Cell Biology·W Zachariae
Sep 22, 2001·Current Biology : CB·B M Stern, Andrew W Murray
Sep 19, 1998·Current Biology : CB·D A Wolf, P K Jackson
Aug 8, 1998·Trends in Cell Biology·F M Townsley, J V Ruderman
Aug 15, 1998·Trends in Cell Biology·C L Rieder, E D Salmon
Apr 27, 1999·Trends in Biochemical Sciences·K Nasmyth
Nov 26, 2010·Quarterly Reviews of Biophysics·David Barford
Oct 13, 2009·Nature Cell Biology·Mathew J GarnettAshok R Venkitaraman
Oct 5, 2011·Nature Cell Biology·Andrew W Murray
Oct 8, 2013·Nature Cell Biology·Philippe CollinJ Pines
Oct 29, 2013·Nature Cell Biology·Stephanie HeinrichSilke Hauf
Aug 10, 2006·Nature Reviews. Molecular Cell Biology·Jan-Michael Peters
Apr 12, 2007·Nature Reviews. Molecular Cell Biology·Andrea Musacchio, E D Salmon
Dec 22, 2012·Nature Reviews. Molecular Cell Biology·Emily A Foley, Tarun M Kapoor
Oct 3, 2002·Nature Reviews. Molecular Cell Biology·Andrea Musacchio, Kevin G Hardwick
Sep 26, 2012·Nature Structural & Molecular Biology·Kristina UzunovaJan-Michael Peters
Oct 20, 1999·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Y M YamashitaMitsuhiro Yanagida
Aug 3, 1999·European Journal of Biochemistry·K A Farr, O Cohen-Fix
Feb 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Adar TeichnerAvram Hershko
Dec 21, 2011·Proceedings of the National Academy of Sciences of the United States of America·Daisuke ItoTomohiro Matsumoto
Jan 26, 2002·Molecular Biology of the Cell·Satoshi KatayamaTakashi Toda
May 15, 2002·Molecular Biology of the Cell·Eunah Chung, Rey-Huei Chen
Aug 6, 1999·Molecular Biology of the Cell·R H ChenKevin G Hardwick
Jul 11, 2000·Molecular Biology of the Cell·J D LeversonT Hunter
Oct 8, 1998·Molecular Biology of the Cell·S L JaspersenD O Morgan
Jun 1, 2004·Molecular Biology of the Cell·Katherine C ChenJohn J Tyson
Jul 23, 2004·Molecular Biology of the Cell·Suzanne VigneronThierry Lorca
Jan 16, 2009·Molecular Biology of the Cell·Ying Lu, Frederick R Cross
Jul 3, 1998·The EMBO Journal·Thierry LorcaJean-Claude Labbé
Nov 29, 2002·The EMBO Journal·Toshiyuki HabuTomohiro Matsumoto
Nov 17, 2011·Human Reproduction Update·Shao-Chen Sun, Nam-Hyung Kim
Dec 3, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Mitsuhiro YanagidaY Nakaseko
Dec 3, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Avram Hershko
Dec 3, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Guowei FangM W Kirschner
May 18, 2005·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Mitsuhiro Yanagida
May 18, 2005·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Anna DeAntoniAndrea Musacchio
Nov 16, 2011·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·David Barford
Jun 17, 2004·Genes & Development·Jing Pan, Rey-Huei Chen
Aug 13, 1999·Genes & Development·R L Tinker-Kulberg, D O Morgan
Mar 21, 2007·Genes & Development·J L Burton, Mark J Solomon
Jul 19, 2001·Genes & Development·J Chen, Guowei Fang
Jan 19, 2002·Genes & Development·Yumei LiStephen J Elledge
May 23, 2003·Cold Spring Harbor Symposia on Quantitative Biology·M Dobles, P K Sorger
Aug 2, 2012·Molecular and Cellular Biology·Jonas O CarlstenXuefeng Zhu
Apr 25, 2000·Molecular and Cellular Biology·K TanakaH Okayama
Jun 10, 2000·Molecular and Cellular Biology·J L Burton, M J Solomon
Jun 29, 2000·Annual Review of Biochemistry·A M Page, P Hieter
May 8, 2009·Cell Structure and Function·Yujian LuHeng Liu
Sep 27, 2013·PloS One·Maria I Davidich, Stefan Bornholdt
Dec 5, 2012·ISRN Oncology·Josep J Centelles
May 9, 2000·Biochemical and Biophysical Research Communications·Y YudkovskyAvram Hershko
Feb 19, 2000·Biochemical and Biophysical Research Communications·A OhtoshiM Hatakeyama
Jun 5, 2003·Chaos·Béla NovákJohn J Tyson
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Ilana BraunsteinAvram Hershko
Jun 23, 1999·Proceedings of the National Academy of Sciences of the United States of America·D C FarruggioJ V Ruderman
Sep 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·K Wassmann, R Benezra
Jan 25, 2002·Journal of Cellular Physiology·Katya RavidMatthew R Jones
Oct 18, 2002·Journal of Cellular Physiology·Sizhi Gao, Robert E Scott
Mar 11, 1999·Current Opinion in Genetics & Development·A Amon
Feb 13, 2001·Current Opinion in Genetics & Development·K Wassmann, R Benezra
Feb 19, 2000·Current Opinion in Genetics & Development·L Cerutti, V Simanis
Jul 3, 2003·Médecine sciences : M/S·Anna CastroJean-Claude Labbé
Sep 26, 2012·The Journal of Cell Biology·Daisuke Izawa, J Pines
Apr 17, 2013·The Journal of Cell Biology·Ivana Primorac, Andrea Musacchio
Jun 12, 2013·The Journal of Cell Biology·Noel LiangaA D Rudner
Mar 8, 2000·The Journal of Cell Biology·Kevin G HardwickAndrew W Murray
Oct 24, 1998·The Journal of Cell Biology·R H ChenAndrew W Murray
Jul 23, 2008·The Journal of Cell Biology·Ayumu YamamotoYasushi Hiraoka
Jan 4, 2001·Drug Metabolism Reviews·P M Flatt, J A Pietenpol
Jun 12, 1998·The Journal of Cell Biology·G J GorbskyAndrew W Murray
Jun 28, 2000·The Journal of Cell Biology·A D RudnerAndrew W Murray
Sep 6, 2001·The Journal of Cell Biology·M A Hoyt
Jun 28, 2000·The Journal of Cell Biology·A D Rudner, Andrew W Murray
Oct 21, 2015·The Journal of Cell Biology·Hui-Ju YangYasushi Hiraoka
Oct 21, 2015·Current Biology : CB·Andrea Musacchio
May 13, 2008·Biochimica Et Biophysica Acta·Saskia J E Suijkerbuijk, Geert J P L Kops
Dec 15, 2015·Developmental Cell·Virginia SilióJonathan B Millar
May 12, 2005·Cell Motility and the Cytoskeleton·Sheila Kadura, Shelley Sazer
Mar 26, 2003·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Takuhiro MatsumuraMitsuhiro Yanagida
Mar 14, 2007·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Yasuyo KobayashiKohta Takahashi
Mar 10, 2006·The EMBO Journal·Marina MapelliAndrea Musacchio
Nov 3, 2011·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Jakob Nilsson
Jun 26, 2015·FEMS Microbiology Reviews·Adrianna SkonecznaMarek Skoneczny
Apr 8, 2006·Experimental Cell Research·James DavenportRakesh Goorha
May 4, 2005·Trends in Cell Biology·Vincent Vanoosthuyse, Kevin G Hardwick
May 11, 2005·Biochemical and Biophysical Research Communications·Yu-Kyung KimKwang-Hyun Baek
May 30, 2015·Molecular Biology of the Cell·Nathaniel I KrefmanGeorjana Barnes
Nov 18, 2003·Annual Review of Genetics·Daniel J Lew, Daniel J Burke
Mar 29, 2014·FEMS Microbiology Reviews·Yuya YamagishiYoshinori Watanabe
May 14, 1999·Current Opinion in Genetics & Development·K W DobieG H Karpen
Mar 1, 2000·Experimental Cell Research·T ListovskyM Brandeis
Feb 2, 1999·Experimental Cell Research·J M CraigP Vagnarelli
Feb 23, 2005·Current Biology : CB·Kevin G Hardwick
Dec 20, 2005·Current Biology : CB·Sabine VaurJ P Javerzat
Feb 28, 2008·Current Biology : CB·Jan-Michael Peters
Nov 15, 2003·Current Biology : CB·Marion A ShonnAndrew W Murray
Nov 24, 2012·Current Biology : CB·Pablo Lara-GonzalezStephen S Taylor
Jun 9, 2004·Current Biology : CB·Bonnie J HowellE D Salmon
May 1, 1999·Experimental Cell Research·J M Peters
Apr 13, 1999·Biochemical and Biophysical Research Communications·T W SeeleyJ Y Zhen
Jun 6, 2000·Current Biology : CB·D M Brady, Kevin G Hardwick
Mar 31, 2005·Cell·K Nasmyth
Nov 21, 2007·Cell·Maojun YangXuelian Luo
Nov 13, 2008·Structure·Xuelian Luo, Hongtao Yu
Feb 7, 2015·PLoS Computational Biology·Claude GérardBéla Novák
Jun 25, 2016·Proceedings of the National Academy of Sciences of the United States of America·Joseph R MarquardtHarold A Fisk
Mar 7, 2001·Current Biology : CB·M S SchwabJ L Maller
Apr 8, 2017·Archivum Immunologiae Et Therapiae Experimentalis·Wiem ChaabaneMarek J Łos
Jul 12, 2003·Nature Cell Biology·Eunah Chung, Rey-Huei Chen
Apr 1, 1998·Nature·T L Orr-Weaver, R A Weinberg
Apr 20, 2007·Nature·Jan-Michael Peters
Jun 2, 2018·Integrative Biology : Quantitative Biosciences From Nano to Macro·Yasmin Z PatersonJasmin Fisher
Nov 13, 2018·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Yanshen YangLenwood S Heath
Jul 25, 2009·The EMBO Journal·Andrea Ciliberto, Jagesh V Shah
Nov 13, 1999·Nature Cell Biology·P Clute, J Pines
Nov 13, 1999·Nature Cell Biology·D O Morgan
Mar 23, 2012·Nature·William C H ChaoDavid Barford
Feb 16, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hyun-Seo LeeKyung-Ah Lee
Feb 1, 2003·The Journal of Biological Chemistry·Yuan ZhouDong-Yan Jin
Mar 17, 2004·Oncogene·Rajnish Bharadwaj, Hongtao Yu
Sep 7, 2004·The Journal of Biological Chemistry·Izumi SugimotoMakoto Nakanishi
Aug 25, 1999·The Journal of Cell Biology·S KotaniK Todokoro
Jun 6, 2019·F1000Research·Hiroyuki Yamano
Sep 17, 1999·The Journal of Biological Chemistry·N SugataK Todokoro
Dec 16, 2020·Molecular Biology of the Cell·Sue BigginsDavid Toczyski
Mar 12, 2009·Molecular Cancer Research : MCR·Miyong YunKee-Ho Lee
Jul 29, 2004·The Journal of Biological Chemistry·Masuo Goto, Edward M Eddy

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