Fissurectomy Combined with High-Dose Botulinum Toxin Is a Safe and Effective Treatment for Chronic Anal Fissure and a Promising Alternative to Surgical Sphincterotomy

Diseases of the Colon and Rectum
Thomas G BarnesAyman S Abdelrazeq

Abstract

There is paucity of data on the long-term outcome of the combination of fissurectomy and botulinum toxin A injection for the management of chronic anal fissure. The aim of this study is to assess the safety, efficacy, and long-term outcome of the combination of fissurectomy and botulinum toxin A injection. This is a nonrandomized prospective cohort study. This study was conducted at a district general hospital in the United Kingdom. The cohort included all patients treated with fissurectomy and botulinum toxin A for chronic anal fissure between September 2008 and March 2012. The patients were treated with a combination of fissurectomy and botulinum toxin A injection. Symptomatic relief, fissure healing, complications, recurrence, and the need for further surgical intervention. One hundred and two patients received fissurectomy and botulinum toxin A injection for chronic anal fissure. At 12-week follow-up, 68 patients had resolution of symptoms and complete healing of chronic anal fissure, 29 patients had improvement of symptoms but incomplete healing and had further topical or botulinum toxin A treatment with subsequent complete healing. Ninety-five patients (93%) reported no postoperative complications. Seven patients reported...Continue Reading

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Citations

Apr 7, 2016·Diseases of the Colon and Rectum·Richard L Nelson
Dec 6, 2017·ANZ Journal of Surgery·Andrew J FitzDowseIan P Hayes
Jul 25, 2019·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Alejandro Andicoechea AgorríaFrancisco Vivoso Piñero
Oct 31, 2017·Techniques in Coloproctology·P RavindranS I White
Jun 9, 2020·Journal of Family Medicine and Primary Care·Setareh SoltanyParisa Alavi Toosi
Dec 12, 2018·Khirurgiia·A A UlyanovE V Kuznetsova
Jul 22, 2020·Journal of Clinical Gastroenterology·Satish S C Rao, Eula P Tetangco
Oct 8, 2021·The American Journal of Gastroenterology·Arnold WaldMassarat Zutshi
Nov 3, 2021·International Journal of Colorectal Disease·Philip RoelandtJan Wyndaele

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