Fistula Plug in Fistulising Ano-Perineal Crohn's Disease: a Randomised Controlled Trial

Journal of Crohn's & Colitis
A SenéjouxGroupe d’Etude Thérapeutique des Affections Inflammatoires du tube Digestif [GETAID]

Abstract

Anal fistula plug [AFP] is a bioabsorbable bioprosthesis used in ano-perineal fistula treatment. We aimed to assess efficacy and safety of AFP in fistulising ano-perineal Crohn's disease [FAP-CD]. In a multicentre, open-label, randomised controlled trial we compared seton removal alone [control group] with AFP insertion [AFP group] in 106 Crohn's disease patients with non- or mildly active disease having at least one ano-perineal fistula tract drained for more than 1 month. Patients with abscess [collection ≥ 3mm on magnetic resonance imaging or recto-vaginal fistulas were excluded. Randomisation was stratified in simple or complex fistulas according to AGA classification. Primary end point was fistula closure at Week 12. In all, 54 patients were randomised to AFP group [control group 52]. Median fistula duration was 23 [10-53] months. Median Crohn's Disease Activity Index at baseline was 81 [45-135]. Fistula closure at Week 12 was achieved in 31.5% patients in the AFP group and in 23.1 % in the control group (relative risk [RR] stratified on AGA classification: 1.31; 95% confidence interval: 0.59-4.02; p = 0.19). No interaction in treatment effect with complexity stratum was found; 33.3% of patients with complex fistula and 30...Continue Reading

References

May 6, 1999·The New England Journal of Medicine·D H PresentS J van Deventer
Oct 3, 2000·Surgery·F MichelassiR D Hurst
Apr 2, 2002·The Journal of Surgical Research·Stephen BadylakRobert Morff
Feb 27, 2004·The New England Journal of Medicine·Bruce E SandsSander J van Deventer
Jan 20, 2006·Diseases of the Colon and Rectum·Eric K JohnsonDavid N Armstrong
Sep 26, 2006·Diseases of the Colon and Rectum·Lynn O'ConnorDavid N Armstrong
Nov 4, 2006·Diseases of the Colon and Rectum·Bradley J ChampagneDavid N Armstrong
Feb 20, 2007·Alimentary Pharmacology & Therapeutics·S PlamondonM A Kamm
Feb 27, 2007·Journal of Surgical Education·C Neal Ellis
Apr 17, 2007·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·M H MuellerT T Zittel
Dec 18, 2007·International Journal of Colorectal Disease·Alois FürstAyman Agha
Apr 1, 2008·World Journal of Surgery·D A LawesT M Young-Fadok
Mar 11, 2009·Diseases of the Colon and Rectum·Dimitrios ChristoforidisAnders F Mellgren
Mar 13, 2009·Diseases of the Colon and Rectum·Bashar SafarSteven D Wexner
May 1, 2009·Diseases of the Colon and Rectum·Jennifer Y WangMadhulika G Varma
May 15, 2009·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·P GargG R Menon
Aug 20, 2009·Diseases of the Colon and Rectum·Thilo SchwandnerMarkus Hirschburger
Feb 25, 2010·Gastroenterology·Jean-Charles GrimaudUNKNOWN Groupe d'Etude Thérapeutique des Affections Inflammatoires du Tube Digestif
Mar 23, 2010·Diseases of the Colon and Rectum·Ali Soltani, Andreas M Kaiser
Jul 16, 2010·Diseases of the Colon and Rectum·Michael F McGeeConor P Delaney
Dec 3, 2010·Journal of Crohn's & Colitis·A DignassUNKNOWN European Crohn's and Colitis Organisation (ECCO)
Jun 19, 2012·Diseases of the Colon and Rectum·Tim W EglintonFrank A Frizelle
Dec 12, 2012·Journal of Crohn's & Colitis·Christine NortonPaul Bassett
Feb 14, 2014·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·M AdaminaM Burnstein

❮ Previous
Next ❯

Citations

Sep 13, 2015·Journal of Crohn's & Colitis·Antonino Spinelli, Paulo Gustavo Kotze
Apr 8, 2017·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·M J LeeUNKNOWN ACPGBI Perianal Crohn's Disease Group
Jun 7, 2017·Current Problems in Surgery·Najjia N MahmoudJohn P Fischer
Jul 14, 2017·Clinical and Translational Gastroenterology·Michael ScharlLuc Biedermann
Aug 10, 2017·Nature Reviews. Gastroenterology & Hepatology·Julián Panés, Jordi Rimola
Jun 20, 2018·Alimentary Pharmacology & Therapeutics·P J TozerUNKNOWN of ENiGMA Collaboration
Oct 10, 2018·Immunotherapy·Jesús Castro-PoceiroJulián Panés
Aug 14, 2018·Inflammatory Bowel Diseases·A Hillary SteinhartChadwick Williams
Mar 22, 2019·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·A Merlini l'HéritierC Brochard
Jul 12, 2017·World Journal of Gastroenterology : WJG·Lucie ThomassinCéline Savoye-Collet
Nov 28, 2019·Inflammatory Bowel Diseases·Meredith FlacsEric Ogier-Denis
Nov 20, 2019·Journal of Crohn's & Colitis·Michel AdaminaOded Zmora
May 22, 2019·Current Drug Targets·Kapil SahnanJanindra Warusavitarne
Mar 17, 2020·Techniques in Coloproctology·G PellinoUNKNOWN Italian Society of Colorectal Surgery SICCR
Jan 15, 2018·Gut·Paulo Gustavo KotzeRemo Panaccione
Aug 1, 2019·Brain Topography·Mohsen Parto Dezfouli, Mohammad Reza Daliri
Jul 9, 2020·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·A HerissayC Brochard
Apr 25, 2018·Inflammatory Bowel Diseases·Charlène BrochardLaurent Siproudhis
Apr 27, 2019·Expert Review of Gastroenterology & Hepatology·Nicole LopezWillam J Sandborn
Dec 5, 2019·Journal of the Canadian Association of Gastroenterology·A Hillary SteinhartChadwick Williams
Sep 21, 2017·Techniques in Coloproctology·D BouchardJ-D Zeitoun
Dec 7, 2018·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·S R BrownUNKNOWN ACPGBI IBD Surgery Consensus Collaboration
Jun 21, 2019·Inflammatory Bowel Diseases·Silvio LauretiGilberto Poggioli
Jun 29, 2018·BJS Open·M J LeeUNKNOWN ENiGMA Collaborators
Dec 6, 2020·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Mathias VidonJean-Marc Gornet
Jan 7, 2020·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Antonino SpinelliGilberto Poggioli
Nov 7, 2020·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Ursula Aho FältLouis B Johnson
Dec 4, 2020·World Journal of Gastroenterology : WJG·Gilmara Pandolfo ZabotWillem Bemelman
Mar 19, 2021·Annals of Coloproctology·Jong Lyul LeeChang Sik Yu
Feb 8, 2021·Journal of Crohn's & Colitis·Bénédicte CaronLaurent Peyrin-Biroulet
Oct 9, 2021·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Laurent AbramowitzDominique Bouchard

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Diseases of the Colon and Rectum
P A Tuxen, A F Castro
Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland
P GargG R Menon
Nederlandsch tijdschrift voor verloskunde en gynaecologie
A Sikkel
© 2021 Meta ULC. All rights reserved