Fit Reduced GUTS Models Online: From Theory to Practice

Integrated Environmental Assessment and Management
Virgile BaudrotSandrine Charles

Abstract

Mechanistic modeling approaches, such as the toxicokinetic-toxicodynamic (TKTD) framework, are promoted by international institutions such as the European Food Safety Authority and the Organization for Economic Cooperation and Development to assess the environmental risk of chemical products generated by human activities. TKTD models can encompass a large set of mechanisms describing the kinetics of compounds inside organisms (e.g., uptake and elimination) and their effect at the level of individuals (e.g., damage accrual, recovery, and death mechanism). Compared to classical dose-response models, TKTD approaches have many advantages, including accounting for temporal aspects of exposure and toxicity, considering data points all along the experiment and not only at the end, and making predictions for untested situations as realistic exposure scenarios. Among TKTD models, the general unified threshold model of survival (GUTS) is within the most recent and innovative framework but is still underused in practice, especially by risk assessors, because specialist programming and statistical skills are necessary to run it. Making GUTS models easier to use through a new module freely available from the web platform MOSAIC (standing fo...Continue Reading

References

Mar 4, 2011·Environmental Science & Technology·Tjalling JagerRoman Ashauer
Jul 7, 2016·Scientific Reports·Roman AshauerThomas G Preuss
Mar 9, 2017·Environmental Science & Technology·Marie Laure Delignette-MullerPhilippe Veber
Aug 27, 2017·Environmental Science and Pollution Research International·Sandrine CharlesMarie Laure Delignette-Muller

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Citations

Mar 2, 2019·Integrated Environmental Assessment and Management·Marco VighiFrancesca Grisoni
Aug 23, 2018·EFSA Journal·UNKNOWN EFSA Panel on Plant Protection Products and their Residues (PPR)Ivana Teodorovic
Jul 14, 2021·Environmental Science and Pollution Research International·Sandrine CharlesChristelle Lopes
Dec 10, 2021··Virgile Baudrot, Sandrine Charles

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