Fitness estimates from experimental infections predict the long-term strain structure of a vector-borne pathogen in the field

Scientific Reports
Jonas DurandMaarten Jeroen Voordouw

Abstract

The populations of many pathogen species consist of a collection of common and rare strains but the factors underlying this strain-specific variation in frequency are often unknown. Understanding frequency variation among strains is particularly challenging for vector-borne pathogens where the strain-specific fitness depends on the performance in both the vertebrate host and the arthropod vector. Two sympatric multiple-strain tick-borne pathogens, Borrelia afzelii and B. garinii, that use the same tick vector, Ixodes ricinus, but different vertebrate hosts were studied. 454-sequencing of the polymorphic ospC gene was used to characterize the community of Borrelia strains in a local population of I. ricinus ticks over a period of 11 years. Estimates of the reproduction number (R0), a measure of fitness, were obtained for six strains of B. afzelii from a previous laboratory study. There was substantial variation in prevalence among strains and some strains were consistently common whereas other strains were consistently rare. In B. afzelii, the strain-specific estimates of R0 in laboratory mice explained over 70% of the variation in the prevalences of the strains in our local population of ticks. Our study shows that laboratory e...Continue Reading

References

Feb 1, 1995·Journal of Clinical Microbiology·S M EngstromR C Johnson
Feb 1, 1993·The Journal of Infectious Diseases·F DresslerA C Steere
Nov 11, 1999·Parasitology Today·S Gupta, R M Anderson
Jul 4, 2001·Trends in Microbiology·D E Dykhuizen, G Baranton
Feb 6, 2002·Trends in Microbiology·Klaus KurtenbachPeter Kraiczy
Mar 8, 2003·Parasitology·D J Conway, S D Polley
Feb 19, 2004·Proceedings of the National Academy of Sciences of the United States of America·Dorothee GrimmPatricia A Rosa
Feb 28, 2004·Lancet·Geoffrey S GottliebJames I Mullins
Sep 18, 2004·Proceedings of the National Academy of Sciences of the United States of America·Wei-Gang QiuBenjamin J Luft
Oct 16, 2004·Transactions of the Royal Society of Tropical Medicine and Hygiene·L HenningI Felger
Oct 30, 2004·Genetics·Dustin Brisson, Daniel E Dykhuizen
Jun 9, 2005·Parasitology·J Piesman, L Gern
Nov 5, 2005·Applied and Environmental Microbiology·Carolin Rauter, Thomas Hartung
May 18, 2006·Emerging Infectious Diseases·Klára HanincováDurland Fish
Aug 9, 2006·Nature Reviews. Microbiology·Klaus KurtenbachNicholas H Ogden
Apr 12, 2007·Journal of the Royal Society, Interface·Marc Lipsitch, Justin J O'Hagan
Dec 7, 2007·Proceedings of the National Academy of Sciences of the United States of America·Andrew R WargoAndrew F Read
May 9, 2008·The American Naturalist·N A HarteminkJ A P Heesterbeek
Jun 13, 2009·PLoS Pathogens·Daniel M WeinbergerMarc Lipsitch
Sep 11, 2009·Ecology Letters·Amy MatserStephen Davis
Feb 5, 2010·Proceedings. Biological Sciences·Caroline O BuckeeKeith A Jolley
Oct 23, 2010·Journal of Evolutionary Biology·O HellgrenL Råberg
Nov 3, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jonathan J JulianoSteven R Meshnick
Jun 22, 2011·Proceedings of the National Academy of Sciences of the United States of America·Andrew F ReadSilvie Huijben
Sep 20, 2011·Vector Borne and Zoonotic Diseases·Dania RichterFranz-Rainer Matuschka
Nov 1, 2011·The Lancet Infectious Diseases·Oliver Balmer, Marcel Tanner
Jun 6, 2012·Proceedings of the National Academy of Sciences of the United States of America·Ivo MuellerIngrid Felger

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Citations

Nov 2, 2018·Proceedings. Biological Sciences·Dolores GennéMaarten J Voordouw
Sep 22, 2019·Applied and Environmental Microbiology·Andrea Gomez-ChamorroMaarten J Voordouw
May 2, 2019·Scientific Reports·Andrea Gomez-ChamorroMaarten Jeroen Voordouw
Jul 12, 2017·Scientific Reports·Alessandro BelliMaarten J Voordouw
Mar 3, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Mehrnaz NouriLars Råberg
May 28, 2020·Trends in Parasitology·Yi-Pin LinPeter Kraiczy
Oct 1, 2020·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Kayleigh R O'KeeffeDustin Brisson

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Methods Mentioned

BETA
biopsies
PCR

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