Fitness is a determinant of the metabolic response to endurance training in adolescents at risk of type 2 diabetes mellitus

Obesity
Martin SénéchalJonathan M McGavock

Abstract

The purpose of this prospective cohort study was to determine whether changes in cardiorespiratory fitness are associated with the metabolic response to endurance training in adolescents at risk of type 2 diabetes mellitus (T2DM). Seventy-three overweight and obese adolescents completed a 6-month endurance exercise intervention. Total fat mass, trunk fat mass, visceral adipose tissue, and liver fat were assessed with dual energy X-ray absorptiometry and magnetic resonance imaging spectroscopy. The change in cardiorespiratory fitness with training was independently associated with reductions in BMI z-score (β = -0.09; P = 0.006), total fat mass (β = -1.40; P = 0.007), trunk fat mass (β = -0.70; P = 0.01), and liver fat (β = -1.80; P = 0.053). Adolescents within the highest tertile of change in fitness were 4.67 (95% CI: 1.15-13.73; P = 0.03), 11.90 (95% CI: 2.37-59.77; P = 0.002), and 6.21 (95% CI: 1.14-33.99; P = 0.035) times more likely to experience decreases in body weight, BMI, and liver fat compared with adolescents in the lowest tertile. The changes in adiposity and hepatic triglyceride content in response to endurance training are significantly related to the increase in cardiorespiratory fitness in adolescents at risk o...Continue Reading

References

Jul 1, 1996·Medicine and Science in Sports and Exercise·J H WilmoreC Bouchard
Jul 7, 1999·The American Journal of Clinical Nutrition·M I Goran, B A Gower
Jul 27, 1999·The American Journal of Clinical Nutrition·M I Goran, B A Gower
Sep 9, 1999·The American Journal of Clinical Nutrition·J H WilmoreC Bouchard
Jun 19, 2001·NMR in Biomedicine·S W Provencher
Apr 27, 2002·The American Journal of Clinical Nutrition·Bernard GutinMark S Litaker
Feb 6, 2003·Medicine and Science in Sports and Exercise·Melissa J MayoGovindasamy Balasekaran
Sep 1, 1994·Obesity Research·C BouchardG Fournier
Aug 19, 2007·Circulation·Jonathan M McGavockLidia S Szczepaniak
Sep 14, 2007·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Ivana ZibLidia S Szczepaniak
May 8, 2009·Nature Reviews. Endocrinology·Robert Ross, Alison J Bradshaw
Jun 9, 2009·Metabolism: Clinical and Experimental·Nicholas D BarwellJason M R Gill
Mar 18, 2011·The American Journal of Clinical Nutrition·Joel Gittelsohn, Megan Rowan
Jan 4, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Shelby SullivanSamuel Klein
Jan 10, 2012·Obesity·Kristy D M WittmeierJonathan M McGavock
Feb 24, 2012·Diabetes Care·Brandy A WicklowJonathan M McGavock
Jul 25, 2012·Journal of Magnetic Resonance Imaging : JMRI·Bharath Ambale VenkateshChia-Ying Liu
Sep 20, 2012·JAMA : the Journal of the American Medical Association·Catherine L DavisBarbara A Gower
Mar 19, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Elisabetta BacchiPaolo Moghetti
Jun 26, 2013·Pediatrics·Martin SénéchalJonathan M McGavock
Sep 14, 2013·World Review of Nutrition and Dietetics·Pilar De Miguel-EtayoLuis A Moreno

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Citations

Jul 8, 2015·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Joseph W GordonJonathan McGavock
Mar 21, 2018·Journal of Sports Sciences·Dominique Silva SilveiraClarice Maria de Lucena Martins
Feb 6, 2021·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Travis J HrubeniukMartin Sénéchal
Aug 17, 2021·International Journal of Sports Medicine·Travis J HrubeniukMartin Sénéchal

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