Fitting the Puzzle Pieces: the Bigger Picture of XCI

Trends in Biochemical Sciences
Cheryl MaduroJoost Gribnau

Abstract

X chromosome inactivation (XCI) is a mammalian-specific process initiated in all female cells, leading to one inactivated X chromosome. The robust nature of XCI, and the complex mechanisms involved in directing this process, makes XCI an important model system to study all aspects of gene regulation. XCI is divided into distinct phases: initiation, establishment, and maintenance of the inactive X (Xi). Recent studies shed important new light on the mechanisms directing all three phases of XCI. These findings include new regulatory pathways in XCI initiation, and the identification of a plethora of new factors involved in establishing and maintaining the Xi. In this review, we will highlight and discuss these new findings in the bigger picture of XCI.

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Citations

Mar 21, 2016·Seminars in Cell & Developmental Biology·Marcella VaccaMaurizio D'Esposito
Feb 2, 2017·Proceedings of the National Academy of Sciences of the United States of America·Smitha SripathyAntonio Bedalov
Dec 29, 2017·Proceedings of the National Academy of Sciences of the United States of America·Lieselot L G CarretteJeannie T Lee
Sep 28, 2017·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·K M Creamer, J B Lawrence
Mar 16, 2017·Frontiers in Molecular Neuroscience·Yuanliang YanZhicheng Gong
Apr 22, 2018·Biochemical Society Transactions·Andrew Keniry, Marnie E Blewitt
Aug 21, 2016·Genes & Development·Lin YangJeannie T Lee
Jun 29, 2021·Frontiers in Cell and Developmental Biology·Wenlun WangLingyun Zhu

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