Five-alpha-reductase Inhibitors for prostate cancer prevention

The Cochrane Database of Systematic Reviews
T J WiltB S Kramer

Abstract

Five-alpha-reductase inhibitors (5ARI) are frequently used to treat bothersome lower urinary tract symptoms associated with benign prostatic hyperplasia and male androgenic alopecia. They have potential as chemopreventive agents. We sought to estimate the effectiveness and harms of 5ARI in preventing prostate cancer. MEDLINE, PreMEDLINE, and the Cochrane Collaboration Library were searched through April 2007 to identify randomized trials. For prostate cancer outcomes we included randomized controlled trials of at least 1 year in duration published after 1984. For non-prostate cancer outcomes, randomized trials were included if: they were at least 6 months in duration published after 1999. The primary outcome was prostate cancer period-prevalence "for-cause." "For-cause" was defined as prostate cancer clinically detected based on symptoms, an abnormal digital rectal exam, or detected as a result of an abnormal prostate specific antigen value. Trials were categorized as long (> 2 year), mid (1-2 years) and short (< 1 year) term. Nine trials reported prostate cancer period-prevalence. Three trials using finasteride lasted 4 years or longer but only one (the Prostate Cancer Prevention Trial) was specifically designed to assess the ...Continue Reading

References

Oct 22, 1992·The New England Journal of Medicine·G J GormleyJ S Tenover
Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Sep 28, 2002·Urology·Claus G RoehrbornUNKNOWN ARIA3001 ARIA3002 and ARIA3003 Study Investigators
Jun 26, 2003·The New England Journal of Medicine·Ian M ThompsonCharles A Coltman
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Dec 19, 2003·The New England Journal of Medicine·John D McConnellUNKNOWN Medical Therapy of Prostatic Symptoms (MTOPS) Research Group
Aug 17, 2006·Journal of the National Cancer Institute·Ian M ThompsonCharles A Coltman
Oct 31, 2006·The Journal of Urology·Anthony V D'Amico, Michael J Barry
Apr 18, 2007·The Journal of Urology·Ian M ThompsonCharles A Coltman
Sep 13, 2007·Journal of the National Cancer Institute·M Scott LuciaIan M Thompson

❮ Previous
Next ❯

Citations

Feb 4, 2009·Journal of General Internal Medicine·Mitchell D WongMartin F Shapiro
Mar 3, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Barnett S KramerUNKNOWN American Urological Association Practice Guidelines Committee
Aug 27, 2009·Therapeutics and Clinical Risk Management·Angela B Smith, Culley C Carson
Jul 17, 2013·International Journal of Molecular Sciences·Nina Pauline HolzapfelDietmar Werner Hutmacher
Jul 28, 2016·Expert Review of Anticancer Therapy·Sherry ZhaoMitchell S Anscher
Nov 11, 2011·The Cochrane Database of Systematic Reviews·Dragan IlicCraig Hassed
Mar 3, 2009·The Journal of Urology·Barnett S KramerUNKNOWN American Society of Clinical Oncology/American Urological Association
Aug 20, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mark R SomerfieldUNKNOWN American Society of Clinical Oncology
Jan 22, 2010·Annals of Surgical Oncology·Ray M Merrill, Bradley D Hunter
Feb 27, 2013·The Cochrane Database of Systematic Reviews·Dragan IlicPhilipp Dahm

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Cochrane Database of Systematic Reviews
T J WiltI R Rutks
The Cochrane Database of Systematic Reviews
T J WiltI R Rutks
International Journal of Urology : Official Journal of the Japanese Urological Association
Koji YoshimuraKazutoshi Okubo
© 2022 Meta ULC. All rights reserved