Abstract
In endemic countries with a high level of chloroquine resistance, Plasmodium vivax malaria is associated with high morbidity and mortality. In these areas, the dihydroartemisinin-piperaquine combination resulted in clinical response, a more rapid clearance of parasitaemia, compared to chloroquine therapies, and reduction of recrudescence or reinfection. We describe five cases of Plasmodium vivax malaria in returning travelers treated with dihydroartemisinin-piperaquine. All patients showed the early parasite clearance and no side effects. Our preliminary results suggest that the dihydroartemisinin-piperaquine combination is effective and safe even in imported cases. A unified treatment policy using the artemisinin combination therapy should be adopted even in non-endemic countries and larger studies are underway to support this strategy.
References
Aug 19, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M E CarliniR L Atmar
Nov 1, 2002·The American Journal of Tropical Medicine and Hygiene·M A BegR A Smego
Mar 6, 2007·Lancet·A RatcliffR N Price
Jun 20, 2008·PLoS Medicine·Emiliana TjitraRic N Price
Aug 22, 2009·The Lancet Infectious Diseases·Ivo MuellerHernando A del Portillo
Jun 1, 2010·The Lancet Infectious Diseases·Nicholas M DouglasRic N Price
Oct 18, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Aung Pyae PhyoFrançois Nosten
Sep 19, 2012·Malaria Journal·Helena H AsklingUNKNOWN European Society for Clinical Microbiology and Infectious Diseases Study Group on Clinical Parasitology
Dec 5, 2012·Antimicrobial Agents and Chemotherapy·Rithea LeangPascal Ringwald
Jan 9, 2013·Malaria Journal·Bridget E BarberNicholas M Anstey
Dec 7, 2013·PloS One·Cho NaingMarcel Tanner
Dec 21, 2013·PLoS Medicine·Nicholas M DouglasRic N Price
Aug 15, 2014·PLoS Neglected Tropical Diseases·Cho NaingJoon Wah Mak
Sep 13, 2014·The Lancet Infectious Diseases·Ric N PriceNicholas J White
Nov 12, 2014·Antimicrobial Agents and Chemotherapy·Jean PopoviciDidier Ménard
Nov 28, 2014·Malaria Journal·Benjamin J VisserMartin P Grobusch
Feb 18, 2016·The Journal of Infection·David G LallooUNKNOWN PHE Advisory Committee on Malaria Prevention in UK Travellers
Aug 28, 2016·Infection·Laura BarradoJesús Castilla
Dec 28, 2017·The American Journal of Tropical Medicine and Hygiene·Angela DevineShunmay Yeung
Jul 8, 2018·Infection·Gianluca RussoCarlo Severini
Jul 24, 2018·The Lancet Infectious Diseases·Robert J CommonsRic N Price
Oct 7, 2018·Malaria Journal·Livingstone TavulIvo Mueller