Five cases of tonsillectomy and steroid pulse therapy for recurrent immunoglobulin A nephropathy after kidney transplantation

CEN Case Reports
Yoshie HoshinoKosaku Nitta

Abstract

Five cases of recurrent immunoglobulin A nephropathy (IgAN) after kidney transplantation were successfully treated by tonsillectomy and steroid pulse therapy (SPT). The clinical background and pathology in the five cases were different, but good results were obtained in all of them. In cases 1 and 2, mild recurrent IgAN developed and failed to remit after tonsillectomy alone, but a remission was achieved in both cases after SPT. In case 3, highly active recurrent IgAN with crescent lesions developed 13 years after kidney transplantation, and a remission was achieved after SPT. In case 4, renal biopsy specimens showed pathological findings of recurrent IgAN with tubulitis, and hematuria and proteinuria resolved after SPT. In case 5, the biopsy findings indicated recurrent IgAN with chronic rejection. Tonsillectomy was followed by resolution of the proteinuria, and a remission was achieved after SPT. In conclusion, SPT is effective in inducing a remission of recurrent IgAN when tonsillectomy alone fails.

References

May 16, 1998·Transplantation·G L BumgardnerF G Vincenti
Sep 5, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A Y WangP K Li
Sep 29, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·O HottaY Taguma
Nov 13, 2001·Kidney International·C PonticelliA Tarantino
Jul 12, 2002·The New England Journal of Medicine·Esther M BrigantiSteven J Chadban
Oct 11, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Bo Ying ChoyKar Neng Lai
Jul 30, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·P ClaytonS Chadban

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Citations

Jan 1, 2019·Nihon Hinyōkika Gakkai zasshi. The japanese journal of urology·Akira TadokoroYoshihiko Tomita

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Methods Mentioned

BETA
biopsy

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