Five complete genomes of JC virus type 3 from Africans and African Americans

Archives of Virology
H T AgostiniG L Stoner

Abstract

The central demyelinating disease progressive multifocal leukoencephalopathy (PML) is caused by the human polyomavirus JC virus (JCV). JCV evolved as geographically based genotypes of which Type 3 is an African variant first characterized in HIV-1 positive patients from Tanzania. This study reports the complete sequence of five JCV Type 3 strains. The entire JCV genome was PCR amplified from urine specimens of three African and two African-American individuals. The African consensus sequence was compared to the Type 1 and Type 2 prototype strains, JCV (Mad-1) and JCV(GS/B), respectively. Type 3 differed in 2.2% of its coding region genome from JCV (Mad-1) and in 1.3% from JCV(GS/B). Within the coding region the sequence variation among the three types was higher in the capsid protein VP1 and in the regulatory protein large T antigen than in the agnoprotein or in VP2/3. Notable Type 3-specific changes were located at sites adjacent to the zinc finger motif and near the major donor and acceptor splice junctions of large T antigen. Four of the five urinary Type 3 strains had an unrearranged, archetypal regulatory region. African strain #309 showed a 10-bp deletion at a location similar to that previously described for #307 from Ta...Continue Reading

Citations

Aug 26, 1998·Research in Virology·H T AgostiniG L Stoner
Feb 13, 2001·Microbes and Infection·G L StonerC F Ryschkewitsch
Sep 5, 2002·Journal of Virology·Makoto SuzukiYoshiaki Yogo
Aug 19, 1997·Proceedings of the National Academy of Sciences of the United States of America·C SugimotoY Yogo
Feb 7, 1998·Proceedings of the National Academy of Sciences of the United States of America·H T AgostiniG L Stoner
Jan 21, 2010·Journal of Medical Virology·Ana MatosAntónio Meliço-Silvestre
Nov 27, 1998·Memórias do Instituto Oswaldo Cruz·S C ChimaG L Stoner
May 26, 1998·Multiple Sclerosis : Clinical and Laboratory Research·G L StonerS Komoly
Dec 7, 2005·American Journal of Physical Anthropology·Tomokazu TakasakaYoshiaki Yogo
Apr 12, 2001·The Journal of General Virology·H T AgostiniG L Stoner
Oct 15, 2013·Journal of Medical Virology·Danijela KaralicTanja Jovanovic
Jul 17, 1999·Medizinische Klinik·J C WasmuthJ K Rockstroh
Apr 18, 2000·The Journal of General Virology·J N Hatwell, P M Sharp
Aug 9, 2006·The Journal of General Virology·Xin Dang, Igor J Koralnik

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.